Parecoxib Sodium For Postoperative Analgesia Analgesic Effect In Patients With Liver And Kidney Function

Objective:To observe the analgesic effect and influence of patients' hepato-renal function by using parecoxib sodium on postoperative analgesia.Methods:60 patients undergoing epidural anesthesia were randomly divided into 2 groups.The patients of A groupⅳ40 mg parecoxib sodium then used PCEA(0.005%morphine+0.24%MSA ropiva-caine) after closed abdomen. The patients of B group only used PCEA(0.005%Morphine+0.24%MSA ropivacaine). ALT, AST, TBIL,γ-GT, Cr, Urea,β2-MG and UA of patients were detected at 24h after operation; VAS score, the palping times of PCEA,incidence rate of the adverse reaction and the scode of Dd/De were observed at 4h,8h,12h,24h after operation.Results:There was no marked change between 2 groups on hepato-renal function, but the VAS score of A group were much lower than that of B group. The palping times of PCEA and the drug consumption of PCEA of A group were less than those of B group. The incidence rate of adverse reaction of A group were much lower than those of B group,and there was no marked change between 2 groups on scode of Dd/De.Conclusion:1.Using paricoxib sodium obviously enhanced analgesic effect and decreased the drug consumption of PCEA.2.Using paricoxib sodium obviously decreased the adverse reaction and improved patients' degree of satisfaction.3.Using parecoxib sodium for postoperative pain had no marked influence on patients' hepato-renal function.