The Value Of⁹⁹Tc^m–MIBI SPECT Gated Myocardial Perfusion Tomography In The Progressive Muscle Malnutrition,s Myocardial Involvement

Objective：(1)Use99Tcm–MIBI SPECT gated myocardial perfusion tomography toevaluate the cardiac involvement in patients with Duchenne musculardystrophy(DMD)and Becker muscular dystrophy(BMD).(2)Through statistical analysis different parts of left ventricularmyocardial involvement and review patiens,Explore the common place ofmyocardial involvement in DMD and BMD patiens, The effect of age onmyocardial involvement.(3)And discuss the correlation factors of left ventricular ejectionfraction(LVEF) reduce in DMD/BMD patients. Find out the most relatedfactors of LVEF.Methods：(1)59DMD patients and13BMD patients were underwent99Tcm–MIBISPECT gated myocardial perfusion tomography, In the59DMD patients,23people underwent electrocardiogram,28people do echocardiography. In the13BMD patients,9people underwent electrocardiogram and11people had doneechocardiography.(2)To statistical analysis the myocardial involvement in the72caseDMD/BMD patients for had done99Tcm–MIBI SPECT gated myocardialperfusion tomography. Patient's left ventricular will be divided into posteriorwall,anterior wall,apex cordis,anteroseptal wall,posterolateral wall,anterolateral wall,posteroseptal wall. Statistical analysis every patient's partsof myocardial involvement. and find out the common area of myocardial involvement. Will ventricular divided into20section, comparison and analysisof the28review patients (DMD23cases,5cases BMD) myocardialinvolvement progress.(3)To statistical analysis the age, EDV, ESV, volume, body mass index(BMI), ventricular area, ventricular score, Mot, Thk, Creatine Kinase (CK)ofDMD/BMD patient's in LVEF≤50%and LVEF＞50%, Find out whether existdifference in these factors.(4)And do Linear-by-Linear Association for the influence factors of LVEFwith age, EDV, ESV, volume,BMI, ventricular area, ventricular score, Mot,Thk, CK. Find out the most relevant influence factors of the reduction LVEF.Results：(1)In the59cases patients with DMD.23patients had doneelectrocardiogram.9cases(39.1%)abnormal.And the others were normal.28patients underwent echocardiography check,12cases(42.9%)abnormal, Andthe others were normal,All the59cases BMD patients were underwent99Tcm–MIBI gated myocardial perfusion tomography,48(81.4%) wereabnormal,11cases has not been seen obvious exception. In the13cases BMDpatients,9patients underwent echocardiography check,4cases(45.6%)abnormal.And the others were normal.11patients underwentechocardiography check,5cases(45.6%)abnormal, And the others werenormal.All the13cases BMD patients were underwent99Tcm–MIBI SPECTgated myocardial perfusion tomography,12(92.3%) were abnormal,1caseshas not been seen obvious exception.(2) In the48cases DMD patients with myocardial involvement.42cases(87.5%) patients are abnormal in the posterior wall,17cases (35.4%) patientsare abnormal in the anterior wall,2cases(4.2%)patients are abnormal in theapex cordis,5cases(%10.4)patients are abnormal in the anteroseptal wall,3cases(6.3%)patients are abnormal in the posteroseptal wall,15cases(31.3%)patients are abnormal in the anterolateral wall,21cases(43.8%)patients are abnormal in the posterolateral wall.In the12cases BMD patientswith myocardial involvement,10cases(83.3%)patients are abnormal in the posterior wall,5cases(41.7%)patients are abnormal in the anterior wall,3cases(25%)patients are abnormal in the apex cordis,2cases(16.7%)patientsare abnormal in the anteroseptal wall,5cases(41.7%)patients are abnormalin the posteroseptal wall,5cases(41.7%)patients are abnormal in theanterolateral wall,1cases(8.3%)patients are abnormal in the posterolateralwall.28cases of review patients with the total of560section, The first timecheck out108section of myocardial involvement, The second detected132section of myocardial involvement, the second compared to the first wereincreased22.2%.(3)There is exist statistical significance of DMD/BMD patiens withLVEF≤50%and LVEF＞50%in age, EDV, ESV, volume, ventricular area,ventricular score, Mot, Thk.And no statistical significance in BMI,CK.(4)The reduced of LVEF factors in proper sequence are ESV(r=-0.88p=0.000),EDV(r=-0.83p=0.000),the area of left ventricle(r=-0.82p=0.000),the volume of left ventricle(r=-0.82p=0.000),age(r=-0.70p=0.000),MOT(r=-0.66p=0.000),Ventricular score(r=－0.54p=0.000),Thk(r=-0.53p=0.000)in DMD patiens. The reduced of LVEF factors inproper sequence are ESV(r=-0.96p=0.000),the volume of left ventricle(r=-0.94p=0.000),the area of left ventricle(r=-0.93p=0.001),EDV(r=-0.92p=0.000),Ventricular score(r=－0.87p=0.000),age(r=-0.80p=0.001),Thk(r=-0.76p=0.003),Mot(r=-0.67p=0.01)in BMD patiens.Conclusion：(1)⁹⁹Tc^m–MIBI SPECT gated myocardial perfusion tomography areobviously better than electrocardiogram and echocardiography for myocardialinvolvement in DMD/BMD patients,It is have statistical significance.(2)Compared with other place of left ventricle, posterior wall were themost position to happen myocardial involvement in DMD/BMD patients,Bythe increased of age, Myocardial involvement and section were increasegradually. (3) There is exist straight line relationship in LVEF with age, EDV, ESV,volume, ventricular area, ventricular score, Mot, Thk.And no straight linerelationship in LVEF with CK,BMI.