Serum High-sensitivity C-reactive Protein Levels And Its Significance In Diabetic Lower Extremity Vascular Disease After Interventional Treatment

Objective:1,To observe the changes of serum high-sensitivity C-reactive protein levelsin diabetes and diabetic patients with great vessels disease, and to investigatethe changes of serum high sensitivity C-reactive protein levels in diabeticlower extremity vascular disease patients before or after interventional therapy(24h,48h,7d,14d).2,To investigate the pathogenesis of diabetic large vascular disease and theeffects that interventional treatment on serum high-sensitivity C-reactiveprotein in order to evaluate clinical effects of interventional treatment and toprovide clinical basis for anti-inflammatory of Diabetic with lower extremityarterial disease as early as possible.Methods: In patients that hospitalized in our departments from May2010toDecember2011we choose30cases of patients with diabetes alone as group A,60of diabetic patients with great vascular disease as group B, from which wechoose20diabetic patients with lower extremity arterial disease that receiveinterventional treatment as group C,20healthy persons at out-patient clinic asa control group D. Conditions selected for group A and B are as follows:Allsubjects were selected consistenting with the1999WHO diagnostic criteriafor diabetes; Diabetic patients with great vascular disease mainly refers to theatherosclerotic of great vessels of the coronary and cerebral arteries, carotid,lower extremity arterial and so on,(Coronary angiography confirmedcoronary heart disease; Head CT diagnosis of cerebrovascular disease;Doppler ultrasonic testing the carotid artery intimal thickening orplaque-media thickness greater than or equal to1.0mm, or there isatherosclerotic performance; Doppler ultrasound or CT angiography confirmed the lower limbs artery was irregularly stenosis segmental occlusion;Cases that with severe infections, trauma, and other endocrine diseases,diabetic ketoacidosis are excluded from the observed objects. Patients ofgroup A and B were supine to draw fasting venous blood so as to test bloodglucose, liver and kidney function, blood fat, glycosylated hemoglobin, highsensitivity C-reactive protein, urine and other index at morning6:00of thesecondary day after admission besides received routine checks such as pairs oflower extremity arterial Doppler bounce or CT angiography,Echocardiography Figure dynamic and ECG.Patients of group C were supineto draw fasting venous blood to do measurements of serum of hs-CRP atmorning6:00after interventional treatment (24h,48h,7d,14d), and theprovisions of the pre-treatment, the different time points after testing the valueof C₀, C₁,C₂, C₃,C₄. Group D under the same conditions were detected forserum hs-CRP,blood lipids, liver and kidney function, glycosylatedhemoglobin and urine and so on.Result: The serum hs-CRP levels of group A is significantly higher thanthat of Group D (P<0.05); The serum hs-CRP levels of group B issignificantly higher than that of Group A (P<0.05); the incidence of largevascular disease for high levels of serum hs-CRP in diabetic patients wassignificantly higher than that of low-level group (P<0.01).the serum hs-CRPlevels of group C before interventional treatment had no significant differencewith group B (P>0.05). The hs-CRP of group C after interventional treatmentof24h,48h was significantly increased compared with that beforetreatment(P<0.01); the levels of hs-CRP after interventional treatment48h washigher compared with24h after treatment(P <0.01).The hs-CRP levels afterinterventional treatment7d had no significant difference with that beforetreatment (P>0.05). The hs-CRP levels after interventional treatment14d hadsignificantly difference with that before treatment (P<0.01).Conclusion:1serum hs-CRP of diabetes and its vascular lesions are closely related, thatinflammation may be diabetes and initiation factor, for diabetes and its prevention and treatment of blood diseases and provides a new train ofthought.2the serum hs-CRP of group C after interventional treatment24h,48h wassignificantly higher than before treatment, indicating inflammatory responsewas enhanced during early interventional treatment stage which can lead torestenosis after interventional treatment, justly, providing a basis for earlyanti-inflammatory to prevent restenosis after treatment.3the serum hs-CRP of group C after interventional treatment14days wassignificantly lower than before treatment, indicating that due to interventionaltreatment the original stenosis or occlusion of lower extremities restoreperfusion, and the blood could circulate freely, at the same time theinflammatory reaction is reduced, so the serum hs-CRP can be used as anevaluation of interventional treatment of clinically effective.