Analysis Of Pregnancy Outcomes Of Hypothyroidism During Pregnancy

Objective: Hypothyroidism during pregnancy is one of the commondiseases in endocrine diseases. Thyroid function has not screenedconventionally to pregnant women in first trimester and which also is notscreened as one necessary item in the guide of pregnancy examination inChina, and hypothyroidism during pregnancy correlates with many adversepregnancy outcomes such as spontaneous abortion, placental abruption, fetalgrowth retardation, anemia, preterm birth, hypertensive disorders in pregnancy,postpartum hemorrhage, stillborn foetus and so on, and may influences thefetal mental development and the developing nervous system. Based onlaboratory testing of the hypothyroidism to pregnant women and screening tohypothyroidism during pregnancy, once the patients are diagnosedhypothyroidism immediately given regulate medical treatment to observe theirpregnancy outcomes after medical treatment and explore the importance ofscreening to hypothyroidism and observe the pregnancy outcomes of patientswith hypothyroidism after given drug intervention.Methods: The prospective screening to301cases who visited obstetricsclinic on admission from November2010to February2012in our hospital,their level of serum TSH, FT3, FT4and TPOAb was determined. The caseswhose thyroid function was abnormal by laboratory testing in twice wereswitched to endocrine clinic in which they are given medical treatment.Application of SPSS13.0statistical software, using Mann-Whitney U ranksum test, X2test, fisher exact test to compare the differences of the incidencesof different pregnancy outcomes and complications and the fetal Apgar store(1min), the birth stature and weight among hypothyroidism treatment group,untreated group and control group in cases, P＜0.05is considered statistical significance.Results: A total of301cases were screened in pregnant women in study,and hypothyroidism patients were89cases; the rate of TPOAb-positive was11.1%.Comparing the early abortionratios in patients with threatened abortionbetween hypothyroidism treatment group and euthyroidism group, thedifferences showed no statistical difference (P＞0.05). The incidences ofmiscarriage, premature birth, spontaneous labor, complications inhypothyroidism untreated group were higher than those in control group, theincidences of natural labor were lower, the differences were either statisticallysignificant (P＜0.05), and the fetal Apgar store(1min), the birth weight andstature were lower than those in control group, the differences were eitherstatistically significant (P＜0.05), but the difference of the incidences ofabdominal delivery was no statistical difference (P＞0.05) in hypothyroidismuntreated group and control group. The incidences of pregnancy outcomes,complications, the fetal Apgar store(1min), the birth stature and weight inhypothyroidism treatment group and control group were no statisticaldifference (P＞0.05).Conclusion: The screening to hypothyroidism during pregnancy in firsttrimester is of important significance. The incidences of pregnancy outcomes,complications, and the birth weight and stature, the fetal Apgar store inpregnant women with normal thyroid function and the pregnant women whowere diagnosed hypothyroidism after screened the thyroid function and givenregulate medical treatment are the same.