| The key methods to cure hepatitis B are effective evaluation technology for state of patients, personalized treatment, and sequential and combination drug treatment. Therefore, Clinical Immunology of hepatitis B workers cry for hepatitis B electronic medical records (HECR) and effective drug evaluation. HECR can help them to manage the information of patients with hepatitis B, as well as assist them for Medical diagnosis. Based on electronic medical records database, efficacy evaluation of drugs with mathematical models, but also has a great application value.The subject started from the research of treatment and mathematical model of hepatitis B. Then, based on the needs of Tongji Medical College Hospital Clinical Immunology Laboratory, we made the use of database management technology, JAVA programming etc. to design and implemented hepatitis B electronic medical record (HECR). After that, focus on data in electronic medical records, this article take advantage of computer recognition and simulation with mathematical models to evaluate efficacy of Lamivudine, Adefovir and combination therapy.The Hepatitis B electronic medical records set information dissemination, information management, diagnosis in one system. It could help doctors to add, edit, delete all types of information of patients, also assisted to understand and analysis the static statistics and trends of laboratory test. HECR meet the practical demands of laboratories and patients, improved the hepatitis B information management in the efficiency and convenience. Drug efficacy evaluation with mathematical model conformed to pharmacology research:(1) Efficacy of Adefovir was better than that of Adefovir; (2) Efficacy of combination therapy was better than that of solo drug. The identification approve that the efficacy evaluation of hepatitis B drugs with mathematical models is scientific. It has a bright future for application. |