Study On The Bioactive Compounds Of Streptomyces Sp. DA22 Associated With Sponge Craniella Austrialiensis

Sponge associated bacteria are important sources for novel natural bioactive compounds. In our previous research, a Streptomyces sp.DA22 was isolated from marine sponge Craniella austrialiensis, which was found to have multiple antimicrobial activities. Some literatures also documented that bacteria of Actinomycetes could generate a series of antibiotics.Seven compounds were isolated from Streptomyces sp.DA22, including 3 new structures, i.e. a new compound N-(4-methyl-1-oxo-3-hexene-1-yl)-L-Tryptophan, and two new derivatives: N-(4-methyl-1-oxo-3-hexene-1-yl)-L-Tryptophan methyl ester; N-(1-oxo-3- hexene-1-yl)-L-Tryptophan. The other 4 compounds include a known compound N-phenylacetyl-L-Tryptophan, which was isolated from microorganisms firstly, a known derivative N-phenylacetyl-L-Tryptophan methyl ester, and two known compounds: Thymine, Uracil.