Synthesis And Biological Activities Of New Quinazolines And Aryloxypropanamides

Chemists have expressed great concern about N-heterocycles because of their good biological activities, such as broad-spectrum, efficient and low toxicity. Many have been developed into a nitrogen-containing heterocyclic compounds and pesticides, new varieties of medicine.Therefore, the research on the synthesis and evaluate their biological activities of new N-heterocycle compounds is very active.In this paper, we studied the synthesis of novel Quinazolines and Aryloxypropanamides derivatives via aza-Wittig reaction, explore the spectral properties of the synthesized compounds and some fungicidal activity.The specific content of this article:1. A series of 2,3,4-tri-substituted-3,4-dihydro-quinazoline derivatives were synth-esized using sequential Passerini/Staudinger/aza-Wittig reaction, the structures of the target compounds were characterized via IR,1HNMR,13CNMR, MS and elemental analysis, and the spectral properties were also studied.This is a synthesis of novel quinazoline derivatives of the new method.2. A consecutively Staudinger/aza-Wittig reaction was developed to construct dihydr-oimidazo quinazoline compounds, and the structures of the compounds were characteriz-ed through IR,1HNMR,13CNMR, MS and elemental analysis, the spectral properties were also discussed.3. We synthesized of nine new aryloxypropanamides derivatives according to the lead compound "fenoxanil",with 2-(2,4-Dichlorophenoxy)propanoic acid as acid component, and the target compounds and the spectral properties of the synthetic conditions were discussed and summarized at the same time.The target compounds were tested inhibitory activity of rice blast fungus.