The Synthesis Of1,2,3-triazoles

The thesis consists of two chapters.In the first chapter, base on positions of the substituted group, we review the synthesis of1,2,3-triazoles. Because of its unique structure and drug activity,1,2,3-triazoles attracted the extensive attention of the biologists, chemists and pharmacologist. So far, they have not been isolated from natural products, but a large number of synthesis method of1,2,3-triazoles has been found and developed. In this paper, we will summarize and review the different artificial synthesis.In the second chapter, An efficient one-pot two-step reaction of acid chlorides, terminal acetylenes, sodium azide and aryl halides is developed for regioselectively synthesis of2,4,5-trisubstituted1,2,3-triazoles. The method is general, convenient, eco-friendly and atom-economical, which could provide excellent yields and regioselectivities. In this part, it is safe, efficient, convenient and environmentally benign.