Research On The Preparation, Drug Delivery Systems, Adsorption And Desorption Of β-Cyclodevrin Polymer Microspheres

In this paper, β-cyclodextrin polymer microspheres were synthesized byinverse emulsion. Epichlorohydrin was used as a crosslinking agent,β-cyclodextrin as the monomer,kerosene as the oil phase. In order to receive thebest preparation condition, uniform design software was used. The stirring speed,reaction temperature, the dosage of crosslinking agent and reaction time wereinvestigated on the influence of the rate of yield and size of polymermicrospheres. The best experimental process was received by using uniformdesign software. Experimental results verify the received results. Theβ-cyclodextrin content, swelling rate, the size of polymer microspheres, surfacemorphology, thermal stability, elements content and crystallinity werecharacterized.Adsorption performance was received with β-cyclodextrin polymermicrospheres as the hydroquinone monomethyl ether carrier, by the use of theLagergrn adsorption dynamics equation and McKay adsorption dynamicsequation fitting, the kinetics characteristics were received. By the use of theisothermal adsorption equation and Langmiur isothermal adsorption equationFreundlich fitting, the thermodynamics characteristics were received. Theinclusion compound were characterizedThe research of slow-release effect of nifedipine-β-cyclodextrin polymermicrospheres was studied with β-cyclodextrin polymer microspheres as drugcarrier. Using orthogonal design software optimized nifedipine-β-cyclodextrinpolymer synthesis process. The inclusion compound was characterized and sustained-release in vitro.The β-cyclodextrin empty microspheres were studied as Pb (Ⅱ) adsorptionperformance adsorbent. The best adsorption conditions were received, and theadsorption process and mechanism were discussed. The isothermal adsorptionthermodynamics and kinetics equation adsorption equation were fitting. Theinclusion compound was characterized.The results indicated:(1) The result showed that the optimum reaction temperature was80℃，reaction time was4h，the amount of crosslinker was8g and stirring speed was1000r/min. The factors affecting microsphere size were stirring speed，andreaction temperature. The factors affecting yield were crosslinking agent，andreaction time. The surface of those β-CD microspheres under optimal conditionswas smooth and had good thermal stability.(2) β-Cyclodextrin polymer microspheres were synthesized from β-cyclodextrin（β-CD）by inverse emulsion polymerization. Thermodynamic andkinetic characteristics as well as the adsorption behavior of β-Cyclodextrinpolymer microspheres for HQMME were investigated. The result shows that within the framework of the study, the Langmuir and Freundlich adsorption isotherm equation were adapted for the adsorption characteristic of β-Cyclodextrin polymer microspheres for HQMME. The enthalpy change ΔH, entropy change ΔS and free energy change ΔG for p-hydroxyanisole adsorbed by β-Cyclodextrin polymer microspheres were all negative at different temperatures. The adsorption was a spontaneous and exothermic process.（3）Using the method of total precipitation to preparation nifedipine β-cyclodextrins microspheres. The influencing factors of medicine microspheres in the drug and the encapsulation efficiency were reaction time, the amount of ethanol, weight ratio of β-cyclodextrins microspheres to nifedipineand temperature. The best results were that β-cyclodextrins microsphereswas1g, coagulant dosage ratio0.02, the amount of ethanol30mL, reaction time3h, temperature40℃. The nifedipine β-cyclodextrins microspheres drug loadings was2.33%, and the seaied rate was74.5%. Using mathematical model research nifedipine β-cyclodextrins microspheres slow-release mechanism, its slow release process of drug release equation with zero level, belong to many kinds of mass transfer mechanism that work together, the process of drug release belongs to the skeleton beta ring paste subtle ball skeleton dissolution and nifedipine spread.The time to adsorption Pb(Ⅱ) balance was7hours, the optimum PH valuewas5.5，β-Cyclodextrin polymer microspheres to Pb(Ⅱ) adsorption process fitMcKay dynamics equation, and Correlation coefficient was0.9989,β-Cyclodextrin polymer microspheres to Pb(Ⅱ) adsorption process fitFreundlich equation and Langmuir equation. Pb(Ⅱ)-β-Cyclodextrin polymermicrospheres crystallinity and thermal stability were lower thanβ-Cyclodextrinpolymer microspheres.