Synthesis And Application Of Anionic Dipeptide Derivatives

Dipeptide can self-assemble into varieties of nanostructures which have shown theunique application advantages and attracted extensive attention in biological medicine fieldof tissue engineering, drug transport, biological imaging and biological sensors. Herein,chiral anionic dipeptides derived from valine and phenylglycine were designed andsynthesized, whose self-assembly behaviors were studied using circular dichroism (CD),field-emission scanning electron microscope and transmission electron microscopy. It wasfound that the chirality of the self-assemblies of the valine derivatives is controlled by thechirality of the valines at the terminals. A series of chiral4,4’-biphenylene bridgedpolysilsesquioxane nanotubes were prepared using the self-assemblies of the dipeptidesderived from valines as the templates and3-aminopropyltriethoxysilane (APTMS) as theco-structure-directing agent through a sol-gel transcription approach. The CD spectra ofthe polysilsesquioxanes indicated that the biphenylene rings stacked and twisted in chiralwithin the backbones. The handedness of the polysilsesquioxanes consisted with that of theself-assembly of the dipeptides. The morphology of the4,4’-biphenylene bridgedpolysilsesquioxane nanotubes were controllable by tuning the volume ratio of the solvents,reaction temperature, concentration and pH value. Moreover, the morphologies ofpolypyrrole were also controlled using the self-assemblies of several anionic gelators as thetemplates, which were sensitive to the volume ratio of solvents and reaction temperature.