Synthesis,Characterization And Interaction Mechanism With DNA Of Three9-anthraldehyde Schiff-base Ligands And Their Copper (Ⅱ)Complexes

Malignant tumor is a common disease that threatens the human heath and has higher mortality in patients. The chemistry therapy is the mostly means in all methods that cure tumour. Many drugs of prevention, therapy and adjuvant therapy in the malignant tumor are design and synthesis with DNA as the target. The antitumor drugs of metal complexes with DNA as the target molecule, their antitumor activity are composed of metal complexes with DNA synergistic action. Metal complexes and some base pairs in DNA conduct chelation, induced tumor cell DNA damage, thus DNA replication and transcription is blocked, destruction the division and proliferation of tumor cell, and induction of apoptosis of the gradually. In the present study, in order to synthesis and screening the antitumor drugs with better prospects for the application. We selected the biologically active small molecules of isoniazid, benzoyl hydrazine, thiosemicarbazide and optically active molecule9-anthraldehyde, synthesis of three9-anthraldehyde schiff-base ligand. Selection of transition metal copper ion and the three ligand preparation of complexes. By element analysis and IR spectroscopy characterizing the structure of ligand and complexes, with the ultraviolet spectrum, fluorescence spectrum and the viscosity method study the interactions mode and mechanism of ligands, complexes and DNA. The experiment results show that the ligands and complexes can bind DNA by intercalation mode. The work of anticancer drugs for the synthesis, screening, drug activity and mechanism of action studies laid theoretical foundation, has strong theoretical research and practical application value.