The Preparation Silica Aerogels Of Different Size And The Research On The Performance Of Load Medicine

Silica aerogel is one kind of Mutifunction mesoporous materials，it has a lot of characteristics andapplications because silica aerogel has porosity、 the lowest density、larger surface area. Therefore, silicaaerogel has a lot of characteristics and applications, such as thermal insulation, sound absorptive, catalysis,adsorptive property and so on. Silica aerogel has a wide range of applications in the new catalysts andcatalytic carrier Because of its high surface area and high porosity, it can be used as a transparent insulatingmaterial, refrigerator insulation, and acoustic impedance coupled materials. As a study of fractal structuraldynamics of the best materials used in integrated circuits, also super capacitor materials, new gas filter, andso has multiple uses.In this paper, the silica aerogel of different diameter be prepared by adding pore expanding,and findsome factors which control and optimization the the pore of silica aerogel.then, further studies the differentdiameter of silica aerogel as carrier and Lovastatin as target drug preliminary performance.First, hexamethylene tetramine、urea、 polyethylene and dodecane amine as pore expanding,usingtetraethoxysilane (TEOS) as the silica source，Silica aerogels were prepared via sol-gel method and ambientdrying process,the pore expanding be added in alcohol gel form before. Factors which influence the poresize of silica aerogels,uch as hydrolysis time and the different roasting temperature wereinvestigated.FTIR、SEM、TG and N2Adsorption/Desorption were used to analysize and characterize theaerogels.Results show that the sample with hexamethylene tetramine keep skeleton structure of silicaaerogels、good dispersivity、good thermal stability and larger pore size;Then, hexamethylene tetramine aspore expanding when the pore size of silica aerogels was bigger than another,he pore size of silica aerogelsno longer get bigger at24h around when hydrolysis time increase from12h to60h,and the pore size ofsamples was increase with the increase of the mount of hexamethylene tetramine and roasting temperatureimprove. The best experimental conditions:The pore size of samples were biggest use hexamethylene tetramineas expanding agent;Hydrolysis time for24h;The amount of hexamethylene tetramine0.044mol/mol TEOS;Roasting temperature for500℃.The pore size of silica aerogels was14.67nm.Secondly,silica aerogels were carried with Lovastatin by adsorption and crystallization in supercriticalCO2.Factors,difference pore size which influence the loading of silica aerogels.FTIR、TG and N2Adsorption/Desorption were used to analysize and characterize the samples.Results show that the loadedsamples both skeleton structure of silica aerogels and skeleton structure of Lovastatin、the absolute quantityof loaded samples were smaller than absolute quantity of silica demonstrate that a little of Lovastatincrystallize in silicas’ pore by BET、the loading rate of silica aerogels up to9.0%(wt%) by TG，the loadingof silica was increase with the improve the pore size of silica.Finally, the prepartion silica aerogel of different diameter,and change some factors which during thepreparation process to control the pore size of silica aerogel formation;In the drug trial,by the rapidexpansion of supercritical solution to prepartion the sample of silica load Lovastatin.Compared the releasecurve of the silica aerogel load Lovastatin and the Lovastatin,it reveal that the sample of silica aerogel loadLovastatin contributing to controlled-release.