Research On Optimization Preparation And Structural Characterization Of Water Soluble Fe@Onion-like Fullerene

With the development of the nanotechnology, magnetic nanoparticles which have large surface and good magnetic advantage show a broad application prospects in the magnetic targeted therapy system. Insourcing iron onion-like fullerenes(Fe@OLFs) have the larger surface area, which can load many drugs, so it is an ideal magnetic targetiong carrier to undertake extensive research. The magnetic and water-soluble properties of Fe@OLFs play an important role in magnetic targeting drug delivery system.In this paper, we chose chemical vapor deposition(CVD) to prepare Fe@OLFs, and controlled the reaction temperature, reaction time and holding temperature time to get the products. The products were of good morphology. In order to obtain the good water-soluble Fe@OLFs, a large number of hydroxyl groups were connected to the surface by concentrated sulfuric acid oxidation. Field Emission Scanning Electron Microscope(FESEM), X-ray Diffration(XRD) were used to characterize the morphology and structure. Fourier Transform Infrared Spectroscopy(FTIR), Ultraviolet-visible Spectroscopy(UV-Vis), Atomic Force Microscope(AFM) were used to analysed the surface of sample. Vibrating Sample Magnetometer (VSM) was used to test the magnetic performance.The in-depth analysis of X-ray Photoelectron Spectrograph was used to reveal the relationship between the water-soluble and the chemical state of carbon, and that between the magnetic property and the chemical state of iron.The results were obtained:(1) Fe@OLFs were manufactured by Chemical Vapor Deposition method. The morphology of particles were similar to the circular. The best preparation process was1000℃for reaction temperature,5min for reaction time,15min for holding time. The particle size of samples were range from50nm to lOOnm, to meet the requirement of the magnetic target materials;(2) The structure of Fe@OLFs has not changed after hydroxylation, there were adhesion in particles. A number of hydroxyl groups were loaded on the surface of the sample by charactization to improve its dispersion and stability in water; The decrease of saturation magnetization was dued to the hydroxyl groups;(3) The electronic combination state of the outermost layer of hydroxylated product was characterized by XPS depth analysis. The presence of49.04%C-OH caused the good water solubility. The existence of56.61%Fe,23.66%Fe3O4and19.73%Fe-OOH provided the high magnetic properties. Elemental Fe played a leading role because of the larger magnetic moment and the more content. The analysis provided the accurate theoretical parameters for the preparation and application of the material.