Highly Efficient Route To Multi-halogenatedγ-lactams Via A Tandem Intermolecular Cross-Metathesis/Kharasch Addition Cyclization

One important objective of contemporary organic synthesis is to develop a method for efficient and fast synthesis of carbocycle and heterocycle. As an important class of synthons for a wide spectrum of natural products and medicinal compounds, γ-lactams have therefore evoked immense interest toward pharmaceutical chemist and synthetic chemist. Up to day, chemist develop a series of method for construction of y-lactams. Such as, acyl-nitrogen bond formation,[3+2] addition, reductive amination and radical reaction.Ruthenium-catalyzed olefin metathesis is one of efficient method for construction of carbon heterocyclic. On the side, Grubbs’ ruthenium alkylidenes, acting as the catalysts for cross metathesis (CM), also as the precatalysts for olefin hydrogenation, isomerization, dihydroxylation, claisen rearragement and Kharasch reaction, have shown immense potential to uncover various tandem reactions. So we designed herein a straightforward method for the preparation of a wide range of γ-lactams via a tandem intermolecular cross-metathesis/Kharasch addition sequence...