Preparation Of Photoactive Core-shell/hollow Particles By Dispersion Polymerization And Fixed Biological Macromolecules

Dispersion polymerization is a new and potential technique for preparingmonodispersity particles with functional group in the surface. The functionalparticles were synthesized by Two-stage dispersion polymerization could beuse to prepare different materials with different structure and morphology.These materials can be applied to in the field of research such as the bindingmaterial, nano loading materials, biological materials and light sensormaterials.We use Two-stage dispersion polymerization to prepare core-shellfunctional particles which surface contained hydrophobic monomer (BPMA orDBPMA) or hydrophilic monomer (DMAEMA) in this paper. We also usedthis method to study a way to increase the content of functional group ofparticles surface. This paper discussed core-shell structure formationmechanism through study the change of structure and morphology of pariticlesin process of two-stage dispersion polymerization. Our research uses a newfunctional monomer which contains structure of benzophenone (BP) and twodouble bonds which called DBPMA. PSt-core was prepared at first stagedispersion polymerization and poly (St-DBPMA)-shell was constructed byslowly adding St/DBPMA mixture into reactor after3h polymerization.Moreover, cross-linked hollow particles could be prepared by removing corein THF and different dissolved time could prepare different Mesh structureand hollow structure particles.We introduced photoreactive agent into the surface of nanoparticles andcross-linked hollow nanoparticles could be further modified by photograftingpolymerization. Core-shell/Hollow particles were exposed to UV light cancouple with protein likes biological macromolecules (BSA), water-solubleoligomer (PEG) and mouse IgG, and hollow particles can be used as a carrierto load magnetic nanoparticles.