Study On The Compound Pharvnkitis Spray Of Dexamethasone And Chlorhexidine

The pharyngitis is one of the common diseases in otorhinolaryngology. It isneglected easily so that it influences seriously human’s health,work and life with highincidence and morbidity. The incidence of chronic pharyngitis accounts for10%to12%of laryngeal diseases according to statistics. This disease always happen adult especiallyfor teacher and singer and the incidence was higher in the city than in the countryside.The dexamethasone sodium phosphate has been a common hormone medicine whichtreats acute pharyngitis. The direct administration in laryngopharyngeal is a kind ofeffective way of administration. The paper relates a sprayer made from dexamethasonesodium phosphate and Chlorhexidine acetate.Firstly, the paper researched the preparation of the compound pharyngitis spray ofdexamethasone and chlorhexidine. The prescription and process was determined bydetermination of specification and selection of solvent and flavoring agent except forthe choice of delivery device.Secondly, the determination and stability analysis method of HPLC wasestablished to control the quality of the compound pharyngitis spray of dexamethasoneand chlorhexidine. The method is accurate and sensitive. The excipient and thedegradation products do not interfere the determination of principal agents.Subsequently, the stability of the compound pharyngitis spray of dexamethasone andchlorhexidine was studied. After effecting factors and accelerated test for the compoundpharyngitis spray of dexamethasone and chlorhexidine, appearance characters, drugcontent and composition were checked. The result showed the performance of the drugdid not change significantly. But it is necessary to do long term experimental fordetermining the period of validity of the drug. These provided the basis for the choice ofpackaging and making the quality standard of the drug. On the basis, the draft on thequality standard of the drug was made for controlling the quality of the compoundpharyngitis spray of dexamethasone and chlorhexidine.Thirdly, the irrigative reactions of rats after their pharynx mucosa were exposed byone or more the compound pharyngitis spray of dexamethasone and chlorhexidine. Theresult showed the pharynx mucosa of rats applied the drug have not difference with ratsapplied the distilled water. In addition, the rats which were applied once by a lot of thedrug were normal in the weight and respiratory and behavioral activity.Finnally, the pharyngitis due to ammonia was considered as the experiment object.The effect of the drug on acute pharyngitis was investigated on the basis of the indexwhich includes appearance (the number of scratching mouth, drinking frequency),pharyngeal situation(whether hyperemia or presenting poinsettia) and pathomorph-ology and ultrastructure of pharyngeal mucosa and tissue section of rats. The resultshowed the compound pharyngitis spray of dexamethasone and chlorhexidine couldimprove obviously the symptoms of all acute and chronic pharyngitis.