| pH-responsive nanodevices play an important role in fields such as controlled drugrelease, intelligent separation, biochemical sensing, ion channel simulation, because of theiradvantages including small size, ease of integration, high surface area and so on. In this thesis,polycarbonate membranes and mesoporous silica nanoparticle were functionally modifiedwith pH-responsive polymer and a pH-responsive nanodevice was constructed, Then their pHresponsive transport properties were investegated. The research works of this dissertation aresummarized as follows:1. A biomimetic pH responsive nanodevice was developed via layer-by-layer assemblyof cationic weak polyelectrolyte polyallylamine (PAH) into the nanopores. The transportbehaviour of cation(MV2+) and anion(NDS2-) though the functional membrane wereinvestegated at pH2.0to10.0. The result show that: at high pH, channels were open to cationsand reject anions; at low pH, channels preferentially reject cations and transport anions. Inaddition, the pKa value of PAH inside the pore decreased. This pH-responsive nanoporousmembrane has potential application value in biological ion channel simulation, constructionof biological nanodevice.2. By using radical polymerization method,2-(dimethylamino)ethyl acrylate and4-vinylphenylboronic acid were modified onto the surface of mesoporous silica and apH-responsive polymer modified nanoparticle were gotten.[Ru(bipy)3]Cl2was employed asguest molecule, and then the release kinetics of the dye molecules were recorded underdifferent pH. The result shows that, p[2-(dimethylamino)ethyl acrylate] modifiednanoparticles have pH responsive, but have release in aikaline conditions too. To enhance itsresponsive property,4-vinylphenylboronic acid was co-polymerized and we got apH-responsive nanodevice with zero release in aikaline conditions and fast responsiveness inacid condition. This new type of pH-responsive nanodevice has good application prospects incontrolled drug release. |
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