Different Membrane Structure On Clarithromycin Carry Medicine Microcapsule Of The Building And Its Slow Release Of Performance Study

Peptic ulcer is a common frequently-occurring disease in the world, it is seriouslyharmful for human health. Helicobacter Pylori (HP) is the important factor that is formation,recurrence and more stubborn of peptic ulcer, and it is also carcinogens, it is risk factors topromote stomach cancer happened. Clarithromycin plays an important role in the treatment ofHP infection. Clarithromycin is semisynthetic14-membered ring macrolide antibiotic, itmainly used for respiratory infection, skin soft tissue infection, chlamydia and h. pylori (HP)infection in clinic. Clarithromycin can reduce gastrointestinal adverse reactions, it have highbioavailability, strong organization penetration and long half-life, etc. However, thetraditional pharmaceutic preparation exist the shortagethat the dose is bigger, residence timeis short in gastrointestinal tract, adverse reaction is serious etc. clarithromycin is made to beslow-release microspheres,it just can control drug release rate and improve the utilization rateof drug, reduce the number of uses, improve patient compliance, reduce the side effects ofdrugs and cover up drug bitter taste. In the preparation of the capsules to use a singlemembrane material as slow controlled release skeleton, the symmetric membraneclarithromycin microcapsule in medicine by solvent evaporation method in4h release slow,release incompletely. So, in order to improve drug cumulative release rate of clarithromycinmicrocapsule in medicine, it can change the membrane structure, one is should add tohydroxypropyl methyl cellulose in ethyl cellulose, using mixed membrane materials as slowcontrolled release skeleton; Another one is to change the preparation methods, the preparationof symmetric membrane clarithromycin microcapsule in medicine is by membraneemulsification and in liquid drying of.The paper is about preparing symmetric membrane and asymmetric membraneclarithromycin in medicine microcapsule by solvent evaporation method and by membraneemulsification method combined in liquid drying method symmetric membraneclarithromycin in medicine microcapsules, the microcapsule is based on to microcapsule form,drug loadings rate, the envelope rate, yield as the evaluation index, and investigated the bestpreparation condition of microcapsule and microcapsule preparation conditions on influenceon the performance of the controlled release. Finally, confirmed the best conditions of microcapsule preparation.When the carrier concentration is4%, ratio of oil to water is1:4,drug dosage is1:2in oil phase, PVA concentration is1.0%, SDS concentration is0.1%inwater phase, the symmetric membrane clarithromycin in medicine microcapsule is the best.however, the different between asymmetric membrane clarithromycin microcapsule inmedicine and symmetric membrane microcapsule is the solvent used the mixed solvents thatmethylene chloride and the chloroform mixed as proportion of2:1, ethyl cellulose andhydroxypropyl methyl cellulose mixed as ratio of6:1~7:1in membrane materials, ratio of oilto water is1:8, drug dosage is1:2~1:3. The best preparation condition by the membraneemulsification method combined liquid in drying method is carrier concentration is4%, ratioof oil to water is1:8, drug dosage is1:2in oil phase, PVA concentration is1.0%, SDSconcentration is0.25%in water phase, membrane aperture of SPG is5.4μm. Investigating theslow controlled release properties of microcapsule, the accumulative release rates in vitro ofasymmetric membrane microcapsule in medicine and the symmetric membraneclarithromycin microcapsule in medicine by membrane emulsification method are better thanthe symmetric membrane microcapsules in medicine by the solvent evaporation method,showing that asymmetric membrane clarithromycin microcapsule and the symmetricmembrane clarithromycin microcapsule in medicine by membrane emulsification methodhave better slow controlled release performance.