Studies On Synthesis And Antifungal Activity Of N-(3,4-Methylenedioxyphenyl) Amide

In the21thcentury, the main pursued objectives are sencurity, efficiency, economy,friendly environment about the development of new pesticides. Medicament andpesticide workers pay attention greatly amides because of their broad-spectrum,highefficiency, in recent years, and they have become the mainstream of new pesticide discovery.In recent years, the antifungal activity or insecticidal activity of some compounds, which of1-methyl-3-difluoromethyl-4-pyrazole-carboxamides and3-(3,4-methylenedioxy-6-alkoxy)acrylamides with sesamol as raw material, was higher than the positive control. In order to findhigher antifungal activity’s and valuable pesticides, the paper designed to use1,2-methylen-edioxybenzene, sesamol, spiro[1,3-benzodioxole-2,1’-cyclohexane] as raw materials,wesynthesized35N-(3,4-methylenedioxyphenly) amide derivatives by alkylaton, nitration,reduction, acylation, of which34derivatives are first studied. The structures of thesecompounds were confirmed by IR,~1H-NMR, and MS.The antifungal activity results showed as fowllows: the35compounds had differerntinhibition rates against the six tested strains at the concentration of100mg/L. C/D had ahigher rate of inhibition and better control effect than other compounds. The inhibition rate ofcompound C against Magnaporthe grisease was up to90.8%and and D against Alternariaalternata keissler was up to88.7%,and they were higher than the positive control triabendazoleand azoxystrobin. Ad against Magnaporthe grisease was up to80.7%. The inhibition rate ofcompounds of B series were less than40%.