A Efficient One-pot Synthesis Of3,4-Dihydropyrimidin-2-(1H)-Ones/Thiones Catalyzed By2-Thienylboronic Acid And Propylcyanide Mite Ester Synthesis

3,4-dihydropyrimidin-2(1H)-ones/thiones’ derivatives exhibitpotent therapeutical and pharmacological properties. The synthesis of3,4-dihydropyrimidin-2(1H)-ones/thiones (DHPMs) have attractedinterests of organic chemists. The first chapter summarize previousresearch on Biginelli reaction and reviews of cyanides acaricide synthesishistory; the second chapter is a variety of (heterocyclic) aromatic boricacid was researched catalyzed the Biginelli reaction. The third chapter isof our independent design acaricide synthesis method. The work incontains:(1)2-thienylboronic acid was used to perform Biginelii reactions ofaldehydes, ethyl acetoacetate, and urea or thiourea. The resulted inone-pot synthesis of the corresponding3,4-dihydropyrimidin-2(1H)-onesin acetonitrile refluxed5hours.(2) Under the optimized conditions, we synthesized Twenty-twocompounds, of which ten are new compounds. The reaction yield and reaction time to obtain satisfactory results, and propose a possiblereaction mechanism is the same time, each new material characterization.(3) Design of new acaricide synthesis, and the synthesis of three novelacaricide.