Multicomponent Synthesis Of Thiopyran And Spiroindole Derivaties

The discourse includes five parts.In the first part, we introduce the concept, advantage and application of multicomponent reaction. The basis for the selection of the subject and creative points were discussed.In the second part, the reaction of aldehyde,2H-thiopyran-3,5(4H,6H)-dione and naphthalen-2-amine under acetic acid conditions were studied. It provided a novel method for the synthesis of the thiopyrano[3,4-b]quinolin-11(8H)-one derivatives.In the third part, we synthesized a series of thiopyrano[3,4-d]pyrimidine derivatives by multicomponent reaction. This method has the advantages of high yield, short reaction time and simple operation.In the forth part, we examined the reaction of aldehyde,2H-thiopyran-3,5(4H,6H)-dione and phthalhydrazide in the presence of a catalytic amount H2SO4at25℃under acetic acid conditions.In the fifth part, we investigated the reaction of isatin, cyclopentane-1,3-dione and enamines(3-methyl-l-phenyl-1H-pyrazol-5-amine,3-amino-5,5-dimethylcyclohex-2-enone, methyl-3-aminobut-2-enoate and2,6-diaminopyrimidin-4(3H)-one) in aqueous medium. The new protocol has the advantage of simple operation and environmental friendliness.All products were characterized by IR,1H NMR and HRMS. Furthermore, the structures of some products were confirmed13C NMR and X-ray analysis.