The Study On Assembly And Release Of Cetirizine In Mesoporous Molecular Sieves

Since val1et-Regi’ for the first time, expanded the research on application ofmesoporous materials to the field of drug carrier, mesoporous materials have attractedextensive attention, and become the research hotspot quickly. In2001, a MCM4monox mesoporous material was published as a transport system for drug for the firsttime, the big cavity and the mesoporous shell structure of the hollow type monoxmesoporous material has gotten a lot of attention, the big interspace can store moredrug molecules than the traditional monox mesoporous material. On one hand, theordered mesoporous on the shell can provide an accesecible pathway for diffusion andmass transfer of drug molecule, on the other hand, it can alter the material exchangewith the outer space by changing the permeability of the shell. The outmost shell canbe made into organic and inorganic material with magnetic or fluorescent property, soit is not only very meaningful but also very economic to explore the usage of thehollow type mesoporous molecular sieve as a new-style drug delivery carrier.This text took traditional mesoporous molecular sieve, hollow type organic andinorganic mesoporous molecular sieve as carrier, cetirizine as the model drug.In orderto study the load performance and release property of the five materials mentionedabove.The cetirizine were packaged to the MCM41mesoporous molecular sieve byphysical adsorption and released to the simulated body fluid in vitro. The effects ofhollow type molecular sieve and traditional mesoporous molecular sieve on theloading and releasing property for cetirizine were also discussed by comparison. Atthe same time, their releasing mechanism was investigated.The results showed that, firstly cetirizine had a larger drug loading in hollowtype mesoporous molecular sieve and a better slow-release effect. Organic type with amuch smaller specific surface area had the best sustained release effect. Secondly thepattern and pore size could both effected dynamics of the releasing of cetirizine fromthe mesoporous carrier. Because of the cavity and the mesoporous outer shell of the hollow type mesoporous molecular sieve, it could have a larger loading space than thetraditional molecular sieve. The narrower diameter of the pore which is about2nm onthe outer shell meant a bigger steric hindrance, so it had a better sustained releasingeffect than the traditional molecular sieve.thirdly study on the interaction betweendrug carrier and disperse medium by comparing the releasing property of cetirizinehollow type mesoporous molecular sieve in medium of different pH. The difference inreleasing rate was mainly due to the different dissociative form of cetirizine indifferent release medium. Cetirizine existed in a molecular form at buffer solution ofpH1.2, which led to a smaller acting force with mesoporous molecular sieve, andultimately it would be much easier for cetirizine releasing.From our experiments results, it could be concluded that mesoporous silicamaterials had a more fascinating drug adsorption/release properties than traditionalmolecular sieve, which mainly owe to its special yolk/shell structure.The non-toxicHMS performed rather high drug loading amount and controlled release pattern,which enabled it as a potential candidate for drug carrier. Our study could providetheoretical foundation for new drug control-released carrier research.