Construction Of Bio-responsive Multi-core/shell Structure

After the1940s, mordern pharmacy came in a new era as the great progress of biochemistry. From the successful synthesis of insulin to various hormones, antibiotics, vaccines, proteins and enzymes, drug is used in cancer therapy, polypeptide recombinant, angiocardiopathy treatment, McAb, and genetic engineering. Most of these drugs are composed of some hydrophobic organic groups (such as benzene and pyridine groups), often resulting in the hydrophobic property, which is not easy to be dissolved and absorbed in hydrophilic environment of human bodies.This issue presents a strategy of encapsulate hydrophobic guest molecule to provide a possible way to absorb and intake hydrophobic drugs under the case of invariant drug properties. The use of functional polymer encapsulating hydrophobic guest molecule can achieve the purpose of water-solubility and bio-responsive (amino acid response) release at the same time. Then the nontoxic inorganic porous material (SiO2) is used to encapsulate the functional polymer again, which can give a big contribution to the stability of drugs due to the bio-compatibility of SiO2. This design of core/shell structure with dully shell structure can provide an effective way to solve the problem of drug absorption in human bodies. Comparing with the traditional single shell structure, this design with dully shell structure has more properties, such as bio-stability, bio-compatibility, water-solubility and bio-responsive. But the synthesis of multi-functional core/shell structure is still a challenge.Based on this novel design, we synthesized the functional amphiphilic polymer nanogels as the inner shell materials to entrap hydrophobic organic molecule firstly to achieve the water-solubility of hydrophobic organic molecule. Then we obtained the final core/shell system after coating of the biocompotable mesoporous SiO2as the outer encapsulation shell to achieve the stable and bio-compatible controlled drug release. We research the synthesis of the functional amphiphilic polymer, and then explore the second encapsulation via porous SiO2. We gain some progresses and provide a new way to design multi-core/shell structure for drug release. All the results were characterized by Scanning Electron Microscope (SEM), Transmission Electron Microscope (TEM), Nuclear Magnetic Resonance (NMR) and Specific Surface Area Analyzer.