The Starch-based Disintegrant Ginseng Tablet Disintegration Time Limits

Disintegrant adhesive tablet physical force required to overcome to join the tablet-And promote the tablet in the gastrointestinal fluid, rapid disintegration into small particles accessories, Tablet disintegration and dissolution often absorb the rate-limiting process. The disintegrant choice is an important factor in tablet prescription design, research and development of excellent disintegrating agents, or the appropriate choice of disintegrating agents and to improve the preparation process according to different characteristics of disintegrant.. will enable the development of the development of the tablet has excellent release properties.At present, tablet disintegrating agents widely used at home and abroad as carboxymethyl starch. Carboxymethy1Starch is an important ethers, with a wide range of uses. With the increasing community demand, carboxymethyl starch has become a hot issue over the years. Study of this important raw material for effective disintegrant is starch.This paper uses five different starch-based raw materials, potato starch, wheat starch, corn starch, sweet potato starch and tapioca starch, carboxymethyl starch preparation method of organic solvent in the same preparation conditions, preparation of raw materials than the same cases that the starch of NaOH, chloroacetic acid molar ratio of1:1.5:0.7the five different starch raw materials, carboxymethyl starch disintegrant and copper salt precipitation method measured the five carboxymethyl starchthe degree of substitution (DS).The five carboxymethyl starch as a disintegrant in different starch-based, ginseng powder-based medicine, and adhesives, wetting agents, tillers, excipients and lubricants for accessories, its tabletprepared five different ginseng tablet disintegrating agent:Ginseng (wheat), ginseng (corn), ginseng (potato), ginseng (sweet potato), ginseng (cassava). Were measured in the control of the good and the same tabletting conditions and tablet size on the pressure of the five ginseng tablets disintegration time, compare their disintegration time difference, screening out the disintegration effect is relatively good disintegration time is short a group of ginseng tablets is ginseng (wheat).Prepared five different disintegrants ginseng tablet disintegration time comparison and contrast five different starch-based disintegrant the degree of substitution (DS), ginseng (wheat), disintegration time limit for the shortestand starch, wheat starch prepared in the same molar ratio (1:1.3:0.7) carboxymethyl methyl degree of substitution (DS) is relatively the highest initial judgment ginseng tablet disintegration time should be prepared carboxymethyl starch degree of substitution (DS) is inversely proportional relationship. Therefore used for further preparation of the best ginseng tablet disintegration carboxymethyl starch, wheat starch starch, prepared by NaOH, the amount of the control preparation, not the mole ratio of five groups of carboxymethyl starch, and the same copper salt precipitation method in order to measure the degree of substitution (DS). The same prescription and tabletting conditions prepared five kinds of ginseng tablets:Ginseng (wheat), ginseng (wheat), ginseng (wheat), ginseng (wheat), ginseng (wheat). By measuring the disintegration time, and ultimately determine the size of the degree of substitution of ginseng tablet disintegration time depends on the use of carboxymethyl starch as a tablet disintegrant, and an inverse relationship, i e, short disintegration time, the degree of substitution:such as the disintegration time, the degree of substitution is small. Considering the relationship between production costs and product quality, to determine the degree of substitution of wheat carboxymethyl starch was0.72.