Controlled Loading And Releasing Of Meloxicam By β-Cyclodextrin Polymeric Network

In this work,β-CDPAA and C18PAA were synthesized through β-CD or C18grafting to Polyacrylic Acid (PAA). The network structure of β-CDPAA/C18PAA was built based on the inclusion association between β-CD and C18. Meloxicam, which amount was determined by UV spectrum, were loaded by β-CD monomer and its polymer networks. The loaded drugs were released due to the degradation of β-CD ring under the effect of enzyme and swelling. The results show that the monomer β-CD complex meloxicam in an equimolar ratio. The inclusion constant K was57M-1. The loading rate of Meloxicam were much slower in free β-CD monomer than in polymeric networks because space steric make the meloxicam desorption from the beta-CD diffcultly, the inclusion constant K of β-CDPAA inclusion meloxicam was307M-1, which is much smaller than that of β-CD. Rheological studies have shown that the alpha-amylase has degraded β-CD to release the drug, but in the mean time they also decomposed the network structure. Thus, the way of α-amylase degradation is not suitable for sustained release of meloxicam. Swelling action could play certain affection at slow-release drugs. Because of the space steric hindrance and system viscosity, β-Cyclodextrin polymeric network is better than β-CD at slow-release drug. When the polymer mass fraction was4%or8%, the time that use the swelling to release drug completely was50hours and180hours. The results show that controlling the concentration of the polymer network system can achieve a purpose that can control slow-release drugs.