Preparation,Characterization,and Biological Application Of Nano-rare Earth Carboxylic Coordination Polymer

Rare earth coordination polymers due to their novel structure and unique optical, electrical,and magnetic properties, they have a mumber of promising application, such as selectivecatalytic, chemical and biological sensing, optoelectronic materials. However, many reportedrare earth coordination polymers with larger size, thus limited its many solution-basedapplications because of the poor solubility. Therefore, we need to scale down the large size ofthe rare earth coordination polymers. The way of tailoring can be divided into the followingcategories:1. Selecting the appropriate ligand and rare earth ion coordination;2. Selection ofappropriate synthetic methods;3. Regulated the experimental parameters such as temperature,time, solvent.In this thesis, the carboxylic acid ligands with linear and three-arm structure, differentpreparation methods as well as the regulation the experimental parameters to explore theimpact on the morphology of Nano-Rare Earth carboxylate coordination polymer. Also, with awater-soluble polymer was introduced to modify the nano-particle so that it can be applied tobiological systems. The main content of the thesis is as follows:1. Polyene carboxylic acid ligand was design and synthesis via the Sonogashira couplingreaction;2. A new kind of Nano-rare earth ligand organic framework materials was synthesis byself-assembly method and CTAB-assisted Solvothermal;3. The synthetic water-soluble polymer PEMG-EDA with RAFT method to regulate theparticle size of the nano-material, and have a good biocompatibility, the results show thatPEMG-EDA with only one carboxyl group, so is able to control the particle diameter ofnano-particles, and cell imaging experiments also confirmed this nano-material can be able toenter into the cytoplasm and appear blue fluorescence.