Oxytetracycline Controlled Release Of Polyvinylalcohol/Cellulose Acetate Butyrate Electrospun Core/Shell Nanofibers

In this study, the core-shell structure nanofibers with cellulose acetate butyrate (CAB) as the shell and Poly (vinyl alcohol)(PVA) mixing with Oxytetracycline (OTC) as the core were prepared by core/shell electrospinning to control OTC release. Scanning electron microscopy (SEM) results showed that the best nanofibers can be obtained when the electrospinning was performed under the following conditions:the concentration of PVA and CAB were4wt%and20wt%, respectively, an applied voltage of25KV and a tip-to-distance of20cm. Transmission electron microscopy (TEM) results showed that the inner diameters and shell thickness of (PVA4OTCx)aCAB200.2core/shell samples with the same OTC contents increased and decreased respectively with the increasing of the flow rate of core solutions. The OTC relesase contents of (PVA4OTCx)aCAB200.2core/shell samples increased with the increasing of release time, the flow rate of core solutions and the OTC contents of (PVA4OTCx)aCAB200.2core/shell samples.Antibacterial activity research suggested that bacteriostatic circle diameter of (PVA4OTCx)aCAB200.2core/shell samples increased with the increasing of antibacterial time, the flow rate of core solutions and the OTC contents of (PVA4OTCx)aCAB200.2core/shell samples.