Preparation And Application Of Trasition Metal Catalysts For C-C Coupling Reaction

Glaser coupling and Suzuki cross-coupling reaction are the most important methods in the construction of C-C bond compounds, and play a key role in the synthesis of natural products, drug synthesis, optoelectronic materials and many other areas. In recent years, many reports about the two coupling reactions are focused on the search for new catalysts, ligands and catalytic system. This paper gave an overview of the research process of the Glaser coupling and Suzuki cross-coupling in recent years, and developed new catalytic systems for the reactions. The main contents included the following two sections:(1) An efficient inorganic-organic catalyst was successfully prepared by covalent immobilization of N,N,N’,N’-tetraethylenetriamine (TEDETA) into the channels of SBA-15via3-chloropropyltriethyoxysilane groups, and then followed by an efficient one-pot method metal adsorption procedure. The synthesized catalyst was characterized by HRTEM, XRD, FT-IR, ICP and TGA, and its catalytic activity was tested in the oxidative homocoupling of terminal alkynes using oxygen as an oxidant at the absence of base. Good to excellent yields was obtained to get1,4-disubstituted-1,3-diynes in the solution of DMSO. Moreover, the catalyst could be reused for several times without a significant loss of activity.(2) Here described a method to stabilize Pd (0) on the surface of hollow magnetic mesoporous spheres (HMMS), with Fe3O4nanoparticles embedded in the mesoporous shell. The catalyst was characterized by TEM, EDX, XRD and VSM. The catalyst showed an efficient activity for Suzuki coupling reaction. The catalyst could be recovered in a facile manner from the reaction mixture and recycled six times without any loss in activity.