Synthesis Of6-Triazole-Linked Glycolipids And Sugar-modified Liposomes Via Click Chemistry And Their Bioacivities Assessments

Carbohydrates are ubiquitous in nature. Owing to their structural flexibility and configarational diversity, they mediate numerous biological and pathological events that relate to human beings. Carbohydrate-protein interactions are the fundamentals of many cellular processes, such as signal transduction, cell adhesion, viral/bacterial infection, fertilization, proliferation, differentiation and immune response, which are of great significance in life science. In this paper, numerous glyco-derivatives have been proposed as antitumor or antivirus agents. We designed and synthesized a serial of novel6-triazole-linked glycolipids via CuAAC click chemistry. Their antitumor activities were assessed though MTT assay.The copper-free click chemistry is a newly developed chemical ligation method, which has many applications in fields of drug discovery and construction of focused structure. We designed and synthesized a series of lipid derivatives containing a cyclooctene functional group in order to construct cyclooctene and glycone modificated liposome by Cu-free click cycloaddition reaction, achieving the aim of targeted drug delievery via suger-protein specific recognitions on the cell surface.