Studies Of Direct Alkylation Of Azoles Under Transition-metal Free Conditions

In the past century, the azole compounds had a wide range of applications in organic synthetic chemistry, organometallic chemistry, materials chemistry, medicinal chemistry, biochemistry and many other areas because of their unique structure and efficient biological activity, and they permeated every aspect of our daily life. Besides, they were closely related to scientific, technological progress, and the survival and development of human.Molecular iodine catalyzed organic reactions with high catalytic activity, mild reaction conditions, good selectivity, easy operation and short reaction time.In this dissertation, we made an overview of the synthesis of azoles and the catalysis of iodine in organic chemistry. And then, we summarized our work. This dissertation was composed of the following four parts:1. We summarized the synthesis of azoles from the two aspects of direct alkylation and cyclization. Because the azole compounds couldn’t be isolated from natural products, the synthetic methods got widespread concerns of chemical workers.2. We made a brief introduction to the physical and chemical properties of molecular iodine and epitomized the application of iodine in organic chemistry.3. Introduce our work:Iodine-induced regioselective direct alkylation of azoles via in situ formed alkyliodide.4. Introduce another work:A facile protocol for N-alkylation of azoles using KOtBu as base under NBS-promoted conditions.