Studies On Fluorescent Probes Of Aluminum Ion And Cyanide Ion

Both metal ions and anions are very important for biochemistry, medical science and the environment. They are widely used in environmental, clinical, chemical, and biological applications. They would generate health risk to human beings when they are in improper quantity. Therefore, detection of these ions is crucial to control the concentration levels in the biosphere and minimize direct affects on human health. The main studies as follows:In chapter1, this chapter introduces the background of our work, describes the definition and the structure of the fluorescent chemosensors, and illuminates the design principles. Especially the fluorescent chemosensors of Al3+and CN-.In chapter2, this chapter introduces four Schiff base derivatives (H2L1, H2L2, L3, H2L4) for Al3+, Among the various metal ions, only Al3+induces the fluorescence enhancement of H2L1and results an "OFF-ON" type sensing with excellent selectivity and high sensitivity in aqueous system. The lowest detection limit for Al3+is0.17μM, which is much lower than the permissible concentration of Al3+for drinking water in China. Furthermore, the fluorescence microscopic imaging also indicates that H2L1could be applied to detect Al3+in biological environment.In chapter3, a new fluorescent chemosensor, sodium2-(2-(1H-benzo[d]imidazol-2-yl)quinolin-8-yloxy)acetate (HL5), based on8-hydroxyquinoline derivative has been designed, synthesized and characterized. Once combined with Hg2+in aqueous solution, HL5displays a fluorescence quenching effect to form the compound mercury(II)(LsHg), which could be fast dissociated by the addition of cyanide in this system so that "ON-OFF-ON" type fluorescence change can be achieved. Cyanide induces the revival of fluorescence of L5Hg and results in "OFF-ON" type sensing with high sensitivity and rapid response in aqueous system. Furthermore, the fluorescence microscopic imaging also indicates that L5Hg is suitable for detection of CN" in biological environment.