The Preparation And Smart Drug Delivery Of Alophatic Poly(Urethane-amine)-based Inorganic/Organic Hybrid Materials

In this thesis, CaC03microparticles and smart responsive polymers such as aliphatic poly(urethane-amine)(PUA) were used to prepare the intelligent hybrid drug release carrier via biomineralization method. The morphology and structure of hybrid materials were charactered by SEM, FT-IR, XRD, EDX and TG. The drug release behavior revealed that the prepared hybrid materials could hinder the permeation of the encapsulated drug and reduce the drug release effectively. In addition, they were pH-and thermo-responsiveness. There are two major sections in this thesis:In the first part of thesis, calcium alginate/CaCO3hybrid membranes with pH-and thermo-responsive drug release properties were prepared under compressed CO2using polyacrylic acid (PAA) as crystal growth additive. Aliphatic PUA with excellent biodegradability, biocompatibility and thermal-responsiveness was employed as the smart responsive component. The interaction between PAA and aliphatic PUA contributed to the formation of compact CaCO3microparticles and the high drug loading efficiency of the hybrid membranes. The content of CaCO3microparticles was controlled by adjusting the reaction pressure, reaction time and the type of crystal growth additive of the biomineralization process. The structure of hybrid membranes was characterized by SEM, EDX, FT-IR, XRD and TG. The results confirmed the successful introduction of CaCO3microparticles on the membrane surface. Moreover, the preparation conditions could affect the content of CaCO3microparticles in the hybrid membranes. Swelling and drug release results revealed that the pH-sensitivity of alginate matrix and thermo-sensitivity of aliphatic PUA could be preserved after biomineralization process. The strength and swelling property of the hybrid membranes could be improved by the introduction of CaCO3microparticle. In addition, the release profile could be sustained, indicating the compact CaCO3microparticles could restrain the permeability of the encapsulated drug and reduce the drug release effectively.In the second part of thesis, sodium polystyrene sulfonate (PSS), PUA and CaCO3were used to prepare CaCO3/PUA/PSS hybrid composites. SEM, EDX, FT-IR, XRD and TG were performed to identify the structure of hybrid composites. PSS was employed as crystal growth additive to control the morphology of CaCO3microparticles. In addition, PSS could combine with PUA under weak-acid conditions, which would improve the bonding force between CaCO3microparticles and polymers. The relative content of inorganic component and polymer had a certain effect on the drug controlled release properties of the hybrid carrier. Drug release results demonstrated that the CaCO3microparticles could restrain the permeation of the encapsulated drug and reduce the drug release effectively. Moreover, the drug release of the hybrid composites was found to be pH-and thermo-responsive due to the pH-responsive property of CaCO3and thermo-responsive property of PUA.