Studying On Asymmetric Oxo-Michael/Mannich Tandem Reaction Of α-amido Sulfone And Nitroolefins

In this article, a series of bifunctional catalysts have been synthesized and applied in the asymmetric oxo-Michael/Mannich tandem reaction of a-amido sulfone derived from2-hydroxybenzaldehyde and nitroolefins. After screening of these catalysts,8a has shown good catalytic performance. We also optimized the reaction conditions, including the loading of catalyst, solvent, base and temperature, good results (up to95%yield,94%e.e. and91:9d.r.)were achieved when the reaction catalyzed with10mol%8a and proceeded in CHCl3,0.4mol/L K2CO3as the base, at0℃.