The Catalysis Study Of Pyrazole Copper Complexes That Acts As A Hydroxylase Mimic

The pyrazole derivative is a heterocyclic compound with two nitrogen atoms. The pyrazole derivative has good electical properties and good bioactivities. It plays an important role in the field of medicine and pesticide. Some of the pyrazole derivatives can be used as redox catalyst. So the study on their synthesis and properties is very interest. In this thesis, the pyrazole derivatives and their complexes with Cu2+were prepared and their coplexes properties were investigated. The results and conclusions were listed as following.1. Ten chalcone derivatives were prepared from acetophenone and aromatic aldehyde. And they were characterized by melt point, IR spectra and’H-NMR spectra.2. Ten pyrazole derivatives were synthsized from the chalcones and thiosemicarbazide, and characterized by IR spectra,’H-NMR spectra. The coordination reaction of the pyrazole derivatives and CuCl2were studied. And ten Cu2+complexes with pyrazole derivatives were obtained and characterized by IR spectra and elemental analysis. It is found that all complexes were1:1, and the center metal were quarter-chelater. The structure was deduced.3. At room temperature, the hydroxylation of phenol was investigated in the presence of H2O2and the complexes by HPLC method. The products of the hydroxylation and degradation were maleic acid, pyruvic acid, hydroquinone, pyrocatechol, resorcinol or benzoquinone. The results show that all the complexes could be used as enzyme model compound. The mechanism of the hydroxylation of phenol was deduced. And mechanism of the catalysis was deduced.4. At room temperature, the hydroxylation of methyl orange was investigated in the presence of H2O2and complexes by TLC method and HPLC method. The products of the hydroxylation and degradation were maleic acid, pyruvic acid, hydroquinone, pyrocatechol. The results show that all the complexes could be used as enzyme model compound. The mechanism of decolorization and degradation of methyl orange was deduced. And mechanism of the catalysis was deduced.