The Change And Significance Of MDSC Of Patients With Non-small Cell Lung Cancer Receiving Therapy

Background and ObjectivesLung cancer is the disease which has the highest incidence in human cancer in the world.especially in China, the incidence of lung cancer become higher and higher in recent years. Surgery, radiotherapy and chemotherapy are the major measure of therapy in lung cancer. Recently, targeted therapy with ERGR-TKI in non-small cell lung cancer acquires huge progress. Lung cancer has high grade malignancy and poor prognosis. Myeloid derived suppressor cells(MDSCs)are a heterogeneous population of cells that expands during cancer, inflammation and infection,and that has a remarkable ability to suppress T-cell responses. MDSC can induce immune tolerance in the development of tumor cell, and is an obstacle in immune therapy. MDSC accumulate in many kinds of cancer, and relates to prognosis in some cancer. But, studies of MDSC is still limited in non-small cell lung cancer patients.To explore the change of MDSC during the therapy in non-small cell lung cancer patients. Analyzing the relationship between MDSC, clinical character and C-reactive protein. Thereby, realizing the significance of MDSC C in non-small cell lung cancer patients. MethodsThe population of CDllb+CD33+cells in peripheral blood leucocytes was determined by Flow Cytometer in129patients with NSCLC and30control subjects. Peripheral blood C-reactive protein was determined as well.Results1. there is higer level of peripheral blood MDSC in NSCLC patients than in healthy person. The differences between the two groups were statistical signifaicance(P<0.05)2. Patients with ⅢⅣ stage have higher level of peripheral blood MDSC than patients with ⅠⅡ stage(P<0.05). And the level of peripheral blood MDSC was irrelevant to the age, sex and histology types.3. The level of peripheral blood MDSC and CRP have positive correlation whatever before or after therapy.4. After remove of tumor,the level of peripheral blood MDSC was reduced in the NSCLC patients(P<0.05). But it is no obvious change in patients who have high level of CRP after surgery. And it is sharp reduced in the patients who have low level of CRP after surgery(P<0.05).5. The level of peripheral blood MDSC is reduced in the NSCLC patients who receive PR to the chemotherapy(P<0.05). And it is no obvious change in patients who receive SD or PD to chemotherapy.Conclusion1. There is higher level of peripheral blood MDSC in NSCLC patients than in healthy person2. The. level of peripheral blood MDSC is reduced in the NSCLC patients who had responsiveness to chemotherapy and after removal of tumor.3. The level of peripheral blood MDSC and CRP have positive correlation.4. High level of peripheral blood MDSC may imply poor prognosis.