Change Of Bacterial Pathogens And Drug Resistance Rates In Children With Septicemia From2003to2011

ObjectiveTo investigate the change of distribution and antibiotic resistance rates of pathogenic bacteria isolated in children with blood culture positive septicemia from January2003to December2011in the third affiliated hospital of Zhengzhou University.MethodsAll the clinical iso-Lates were analyzed retrospectively from children with blood culture positive septicemia from2003.1to2011.12in the hospital. Distribution and resistance of pathogens were analyzed in2549culture positive samples.The results were divided in to three groups, the first group(2003.1-2005.12),the second group(2006.1-2008.12),the third group(2009.1-2011.12).Antibiotic susceptibility was Tested by Kirby-Bauer and Kruskal Wallis method. Using SPSS17.0statistical package to analyze, and P value less than0.01indicated statistical significance.ResultsA total of2660clinical isolates were collected, including1804(67.81%) strains of gram-positive cocci and513(19.28%) strains of gram-negative bacilli. Totally137 species were identified fungus, predominantly were Candida albicans (89.05%), whose family distribution of clinical department is neonatal intensive care unit.The most common gram-positive cocci were Staphylococcusaureus, Staph epidermidis, Staphylococcus heamolyticus.The proportion of the gram-positive cocci decreased significiantly since2003,The most important gram-negative pathogens were Kleb-siellapneumoniae,Escherichiacoli, Pseudomonasaeruginosa; while that of the bacilli and fungus increased gradually.The proportion of Kleb-siellapneumoniae and Escherichiacoli increased relatively since2003. Staphylococcusaureus and Staph.epidermidis were susceptible to vancomycin,but highly resist to penicillinscephalosporins.The resistance of K.pneumoniae and E.coli to penicillins and cephalosporins has also increased.But they were relatively susceptible to meropenem, imipenem,piperacillin/tazobactam.Conclusionsl.In children with septicemia, the proportion of the gram-positive cocci decreased significiantly,while that of the bacilli and fungus increased gradually. The most common gram-positive pathogens were Staphylococcusaureus and Staphylococcus epidermidis;The most important gram-negative pathogens were K.pneumoniae and E.coli2. The fungal septicemia were most common in NICU.3.In children with septicemia, K.pneumoniae, E.coli, Staphylococcusaureus and Staphylococcus epidermidis were highly resist to penicillins and cephalosporins. But Staphylococcusaureus and Staphylococcus epidermidis were susceptible to vancomycin K.pneumoniae and E.coli were relatively susceptible to meropenem, imipenem, piperacillin/tazobactam.