| Backgroud: In recent years, the incidence of burning mouth syndrome is rising, it has become acommon disease of the oral mucosa. People do not know much of its cause, so clinical effect oftreatment is not beautiful. At present, there is no effects of therapy, the main adopts the cure forsuspicious pathogeny or comprehensive treatment. The cause of the disease is complicated, itmay be one or more causes. So we have been looking forward to with burning mouth syndromehave more extensive, thorough research, let more patients get rid of the pain of the disease.Burning mouth syndrome (BMS), which happens in the tongue department and other parts of theoral mucosa, the burning pain in the main performance of the sample for a group of syndrome.And some scholars call it tongue pains, tongue feel abnormal, mouth feel abnormal, oraldiscomfort disease, and so on. Now, more accepted has higher incidence in women’s menopauseor the late menopause. The body of estrogen dropped, there was close relationship with thedisease. Oral cavity mucous membrane microcirculation is one of the causes of BMS, it showsvaso-motor disorder, the balance changes of vaso-motor factor and the changes ofhemorrheology. Thus, it produces dental symptoms and causes BMS. This can be provided theuseful clues for the prevention and control of BMS. It plays a role in making it more safely andeffectively for clinical diagnosis.Objective: By simulating the conditions of the decline in estrogen to build model, in order toobserve shrinkage factor (endothelin, ET) and relaxing factor(calcitonin gene-related peptide,CGRP) of blood vessels of oral mucosa changes in the balance and hemorheology. And furtherexploring the oral mucosal microcirculation disorders caused by vasomotor effects of BMS. It isgood for clinical prevention and treatment of BMS to open up new treatment ideas.Methods:30healthy Wistar rats, which are keeping the same conditions. They are divided intotwo groups randomly, compare group and experimental group of15.Compare group received notreatment, it was given conventional diet. Experimental group was implemented the ovaryremoval surgery, it was removed bilateral ovarian and ligated bilateral oviduct tubes. Abdomenwas sutured. The experimental group was fed normal diet like with the compare group. Theywere feeding to9weeks to complete modeling. Under local anesthesia, rats were removed thecavity for arterial blood hemorheology. After the animals were killed, we took the base of thetongue because it was obvious at the vascular tissue. Through using immunohistochemistry, wedetected of endothelin(ET), calcitonin gene-related peptide(CGRP) in the oral mucosa in twoanimals the changes in expression levels. And their changes were caused by the disorder of vasomotor.Results:①In experimental group, after ovariectomy in rats, estrogen levels dropped in theirbody. Gray value of ET was significantly lower than compare group (P<0.01).And the grayvalue of CGRP was significantly higher than compare group (P<0.01). Difference between thetwo grous before and after comparison, difference was statistically significant (P<0.05).②Inthe hemorheology, experimental group was significantly higher than compare group. Theviscosity of blood increased and the flow of blood slowed. Between the two groups incomparison was significant(P<0.01).Conclusions: By simulating the conditions of the decline in estrogen to build model, it canchange the active substance ET, CGRP changes in balance. Both together can be expressed asvasomotor disturbances. At the same time, the viscosity of blood increased and the flow of bloodslowed. Resulting in oral mucosa microcirculation, oral symptoms. Leading to the occurrence ofBMS. |
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