Significance Of Tumor Markers AFP,CA125,CA199and CEA In Patients With Liver Disease

Objective: Any chronic liver disease has close relationship with livercancer. Now, the main task of clinical treatment for liver disease is finded theearly cancer of the liver and slowed the progress of the disease. AFP as specificliver tumor marker has been applied to clinical, like liver cancer diagnosis andscreening measures. With the development of the study of tumor markers,people found that AFP, CA199, CEA, CA125in the neoplastic liver disease(viral hepatitis and liver cirrhosis) also have different elevated. To Exploretumor markers AFP, CA125, CA199and CEA in viral hepatitis and livercirrhosis patients diagnosis and the treatment of guidance applications, andestimate the role of4indicators in evaluation liver damage degree andearly detection liver cancer.Methods: The321Patients with liver disease admitted to digestinginternal medicine department of Jilin university first hospital fromJanuary2010to December2011were chosen.1.104Chronic hepatitispatients （mild41cases, moderate38cases, severe25cases）.159posthepatitic cirrhosis(66compensation,93decompensated period, ofwhich76cirrhosis with ascites,83cirrhosis without ascites). Automaticelectrochemical technology of light was used to detect the serum AFP,CA125, CA199and CEA levels in these patents.2.62chronic hepatitisB virus,42patients hepatitis C virus: investigate the relationship betweenHBV DNA uantification and concentration variation ofAFP,and therelationship between HCV RNA quantification and concentration variationofAFP.3.To detect the serum AFP,CA125,CA199and CEA levels in58liver cancer patients （42primary liver cancer，16metastatic liver cancer）. The statistical methods is used SPSS17.0statistical software.Results: The AFP and CA199levels in patients with chronic hepatitiswere obviously higher than those in control groups,the AFP levels in mild,moderate, and severe groups were2.51,4.55and12.6ng ml-1,the CA199levels were11.62,17.13and42.5U ml-1, with a rising trend diseaseprogression, the difference was statistically significant. The AFP positie were22%,28.9%and44%in patients with chronic hepatitis. The CA199positie7.3%,26.3%and68.0%in patients with chronic hepatitis (P <0.05). theCA125levels in mild, moderate, and severe groups were13.1,13.55and25.1U ml-1higher than those in control group (P <0.05), the CA125levels inmoderate higher than severe groups (P <0.05), but no statistically significantdifference between moderate and mild groups (P>0.05). The CEA positiverate hepatitis and liver cirrhosis groups had no significant difference (P>0.05).The AFP,CA199and CA125in between decompensation patients withliver cirrhosis were20.2ng·ml-1,62.44U·ml-1and265.60U·ml-1, weresignificantly higher than those in compenstatory cirrhosis(9.8ng·ml-1,36.51U·ml-1,and35.10U·ml-1)(P <0.05). The AFP level of HCV groups were3.02ng ml-1much higher than normal control groups (P <0.05). The AFPlevel of serum increased along with the increased of RNA copies number ofHCV. RNA copies number of HCV were significantly coeerlative to serumAFP in patients with hepatitis C virus, correlation coefficient of0.598(P <0.05). The AFP level in Chronic hepatitis B patients were8.65ng ml-1muchhigher than normal control group (P <0.05). The AFP level of serum did notincreased along with the increased of DNA copies number of HBV. DNAcopies number of HBV were weak coeerlative to serum AFP in patients withhepatitis B virus, the correlation coefficient for0.254(P>0.05). The serumAFP, CA199levels in patients with Cirrhosis with ascites groups were23.1ngml-1and72.43U ml-1much higher than Cirrhosis without ascites groups (P < 0.05), but the serum AFP and CA199levels were not correlation with theascites quantity, the difference was not statistically significant (P>0.05). Theserum CA125level in Cirrhotic with ascites was367.35U ml-1.The CA125levels in a few, moderate, and large ascites quantity of Cirrhosis groups were80.80U ml-1,378.40U ml-1and502.60U ml-1, The CA125level of serumincreased along with the increased of ascites quantity, the differences arestatistically significant (P <0.05). The AFP, CEA, CA125and CA199levels inLiver cancer patients were138ng ml-1,3.31ng ml-1,170.05U ml-1and199-Uml-1. There was a statistical difference of AFP and CEA between metastatichepatic carcinoma and primary liver cancer.However,the CA125and CA199levers in metastatic hepatic carcinoma and primary liver cancer were similar.Conclusion: The AFP and CA199levels are increaesd with the degreeof liver damage. RNA copies number of HCV were significantly coeerlativeto serum AFP in patients with hepatitis C virus. DNA copies number of HBVwere weak coeerlative to serum AFP in patients with hepatitis B virus.CA125has early diagnosis value in trace ascites.The AFP and CEA can beused to identify metastatic hepatic carcinoma and primary liver cancer.