Clinical Manifestations And A Study On Etiology In Neonatal Enterovirus Infections

Objectives: The purpose of the study was to investigate the correlationbetween clinical features and etiology of neonatal enterovirus infection, inparticular, enterovirus71(EV71), Coxsackie A group of16(CoxA16),echovirus30type (E30) and Deputy echovirus infection in newborns; andinfected with the clinical features and season, age and sexdistribution． Experiment Methods: Collecting stool specimens of584casesof hospitalized newborns in January-December in2011, we adopted reversetranscription-polymerase chain reaction (RT-PCR) to detect of EV Universal,EV71, CoxA16, E30and vice Aye virus, and reexamined the stool specimens ofenterovirus infection for the EV Universal after two weeks; At the sametime,we drawed the blood for rountine analysis, glucose test, liver functiontest, serum creatine kinase and other tests; At last,we analyzed the clinical dataand drawed a conclusion．Results: In2011,the positive rate of neonatalenterovirus infection is11.98%(70/584) in chang-chun children’s hospital.among them the positive rate of EV71was11.43%(8/70), CoxA16, E30andvice ella were not detected; EV infection has seasonality, the highest peak ofthe month is July and August; sex ratio is1.5:1(men: women); the highest peakof the age of20to28days old; The clinical mainifestions of enterovirusinfection are diarrhea, fever, rash, circulatory disorders, myocardial damageetc，fever is the common mainifestion in the newborn children of enterovirusinfection；fever:58.57%(41cases), Diarrhea：57.14%（40cases）; refusing tomilk:14.29%（10cases）Vomiting：17.14%（12cases）; Skin rashes：32.86%（23cases）; Myocardial injury (ecg myocardial ischemia, increasedmyocardial enzy-mees):29.41%;Neurological complications (jumped/tremor/ ejected milk/sleepiness):22.86%, respiratory complications (bronchitis,bron-chial pneumonia)55.71%. In the positive cases, we reexamine the stoolspecimens of enterovirus infection after two weeks,the EV positiverate:90%(20case-s), The infants of EV71infection: fever:100%; rash:75%;the feature of rash:lasting about3days, leaving no trace, having differentcharacteristics with rash of children of HFMD; After treatment, the infants ofenter-ovirus infection were clinical cure.Average day in hospital is8.83±1.79days. Conclusions:1.There are enterovirus infection in newborn children, andthe main type of enterovirus in2011is EV71；2.Neonatal enterovirus infectionhave obvious seasonality (July to August)；3.The high risk age of enterovirusinfection is20-28days old；4.The clinical mainifestions of enterovirus infectionare diarrhea, fever, rash, circulatory disorders, myocardial damage etc, fever isthe common mainifestion in the newborn children of enterovirus infection；5.After two weeks the stool specimens of neonate of enterovirus infection testpositive.