Application And Study Of The Role Of Splenium Of Corpus Callosum In Words Processing

ObjectiveThe main goal of this study was to anticipate whether the lesion in the splenium of the corpus callosum (SCC) is reversible by neuropsychological tests.Subjects&MethodsLesions in the SCC on MRI they were characterized by high signal intensity on FLAIR and FSE T2-W sequences, with minimal or no signal reduction on T1-W sequences and no contrast enhancement. On DWI SCC lesions are hyperintense with low apparent diffusion coefficient (ADC) values, reflecting restricted diffusion due to cytotoxic edema. We administered neuropsychological tests to the two patients with lesions in the SCC. We focused on whether the patients had left hemialexia. More specially, we asked whether the lesions was reversible coincided with our anticipation through the magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI).ResultsOne patient had the left hemiparalexia or left hemialexia. MRI displayed the lesion in the SCC remained, and DTI showed that the nerve fiber in the SCC broken in this patient6months later. The other hadn’t the left hemiparalexia or left hemialexia. After16days, MRI displayed the lesion in the SCC almost disappeared, and DTI showed that the nerve fiber in the SCC reserved in this patient.ConclusionsThe lesion in the SCC has been found in patients with several different conditions. Whatever conditions have happened, we cannot know the splenium lesion is reversible or not, because they have same magnetic resonance imaging pattern in the early stage of disease. Tachistoscope reading is a good method to decide whether cytotoxic edema of the SCC is reversible or not. If patients had left hemialexia or left hemiparalexia, the lesion in the SCC may be irreversible. On the contrary, if patients had not left hemialexia or left hemiparalexia, the lesion in the SCC may be reversible.