The Applied Study Of Susceptibility Weighted Imaging In The Glioma Preoperative Classification

Objective Compare the correlation and the diagnostic accuracy between intratumoralsusceptibility signal intensity(ITSS) and relative cerebral blood volume(rCBV) for gliomaspreoperative classification, to explore the clinical value of susceptibility weightedimaging(SWI) for assessing gliomas classification.Material and methodsObject of study:collecting thirty-eight patients with gliomas in our hospital,Therewere22males and16females,age17-69years,and the mean age was44.8.the number ofⅠ, Ⅱ, Ⅲ, Ⅳ were4,8,15,11cases respectively,which confirmed by pathologically.Method of examination:All patients received examination by using GE Signa HDx3.0T MR. And head-neck joint eight channel coil. The sequence was respectivelyconventional T1WI and T2WI, SWI adopt entirely speed compensated3D GREsequence,PWI adopt GRE-EPI sequence. Finally, the sequence was conventional contrastand contrast enhanced SWI.the contrast medium was Gd-DTPA.Image analysis:The raw data were transited to the workstation after scanning,and werepostprocessed by functool software, the data after SWI scanning could obtain the MIPmaps with10-12mm thickness reconstruct. Subject to the susceptibility effect of themagnitude map,and analysis images combine with phase maps,MIP maps were used toobserve the vein or slightly bleeding of tumors, make sure the ITSS classification.the CBVmaps were obtained by reconstruction after PWI scanning, calculated CBV values of theROI by selecting the richest zone of tumor blood supply.and analysis ITSS and rCBVvalues of the same level.Statistical analysis:Using SPSS17.0for windows statistical software to analyse the data,tested the Homogeneity of variance and Normal distribution before statistics. Tocompare the differences of the ITSS classification among different pathological grades andthe differences of the rCBV values among different pathological grades. And analysis thecorrelation between ITSS、rCBV values and pathological grades.Receiver operatingcharacteristic(ROC) curve analysis were performed to evaluate the diagnostic accuracy oftwo methods.Results Kruskal-wallis test showed significant difference of ITSS classification werefounding in different pathological grades(p<0.001), ANOVA test show rCBV values weresignificant difference among the different pathological grades(p<0.001).Spearmancorrelation analysis showed there was positively correlated between ITSS classificationand the pathological grade(r=0.656,p<0.001); there was positively correlated between therCBV value and the pathological grade(r=0.840,p<0.001);there was positively correlatedbetween ITSS classification and the rCBV value(r=0.652,p<0.001).The ROC curve showsthere were a higher diagnostic accuracy with ITSS classification and rCBV value.the areaunder the curve were respectively0.851and0.939.the specificity and sensitivity in thehigh-grade gliomas were respectively0.667、0.808and0.917、0.962.Conclusion (1)SWI can be used to assess the pathological grading of glioma,both ofwhich have a high diagnostic accuracy compared with PWI, while the perfusion weightedimaging have a higher diagnostic accuracy.(2)ITSS classification of non-contrast enhancedSWI keep consistent with contrast enhanced SWI.