Clinical Research Of Treating Hypokinesia Type And Rigid Type Parkinson’s Disease With MaFuXin Decotion

ObjectiveAlthough the course of Parkinson’s disease (PD) is long and the treatment is difficult, it provides a very long treatment time for us at the same time. Therefore, we should make use of this good opportunity and develop the TCM treatment of PD, which is one of the direction that we work hard. This research observes the MaFuXin Decotion’s clinical curative effect, trying to look for a new way to treat the PD.MethodThis study elects the PD patients as studied objects to take a prospective random parallelism comparison survey. These patients were grouped randomly into two groups:twelve in either group. We gave the Treatment Group (TG) MaFuXin Decoction and madopar one dose per day. And the Comparison Group (CG) takes the madopar referring to the randomization, the dose was as same as Treatment Group. The test ran referring to the test requirement rigorously. At last, All cases of TG and CG has not been lost. Observing cycle of the two groups were both three months. SPSS17.0software was used to handle datum. T-test was used to handle quantitative datum、the chi-square test was used to handle categorical datum and the wilcoxcon rank sumtest was used to the ranked data.ResultPrior treatment, gender、age、course of disease、H-Y grading of pathogenic condition、UPDRS score、PDQ34score and medication of the two groups had no statistical difference(p>0.05). the basal line of two groups is coincident, and with comparability.The outcome shows:Contrast the integral of UPDRS of two groups of prior-treatment, the TG’s integral of post-treatment of mind、behavior and emotion、ordinary activity、movementfunction had decreased than that of prior-treatment. The difference is significant (p<0.05).The CG’s integral of post-treatment of UPDRS scale is not improved significantly (p>0.05)Contrast the integral of the PDQ34of two groups of prior-treatment to which of post-treatment, the TG’s score of post-treatment had discreased than that of prior-treatment. The difference is significant (p<0.05).And the improvement ratio of the integral of the PDQ34scale of two groups of post-treatment, the TG is superior to the CG.Before and after treatment, twelve patients of both groups,which have undergo the routine blood, urine, electrocardiogram, liver and kidney function tests, were not found the abnormal changes related to treatment.Conelusion1.MaFuXin Decoction is an effective prescription for hypokinessia type and rigid type PD.2. The basic pathogensis of hypokinesia type PD is deficiency of yangqi with losing nourishing of muscle and tendon。Therapy of this disease should be based on yangqi and the principle of treatment is warning yang for expelling cold、 promoting blood circulation and removing obstruction in channels, which has been proved effect clinically。3. The quality of life had been improved significantly in test group than that in control group。...