Metformin Sensitizes Endometrial Cancer Cells To Chemotherapy By Repressing Glyoxalase I Expression

Objective:Metformin plays an important role in inhibiting cancer cell growth and has other anticancer properties. Thus, the arm of this study was to investigate the effect of metformin on chemotherapeutic sensitivity in endometrial cancer cells and explore the potential molecular mechanism.Methods:MTT array was performed to determine whether metformin enhances the cell-killing induced by chemotherapeutic drugs. RNA interference and overexpression Glol was used to determine the potential molecular mechanism of metformin sensitization of cancer cells to chemotherapy.Results:Combined therapy with metformin and chemotherapeutic drugs enhanced chemotherapy sensitivity to the administration of cisplatin and paclitaxel. which is associated with reduced Glol expression.Conclusion:Metformin enhances the cell-killing induced by chemotherapeutic agents by repressing Glol expression.