Levels Of Peripheral Blood Stem Cell Factors In Patients With Chronic Kidney Diseases

BACKGROUND:Stem cell factor is a multifunctional cytokine, which plays a crucial role in the process of renal interstitial fibrosis.OBJECTIVE:To investigate the changes of serum stem cell factor(SCF) level in patients with chronic kidney disease(CKD) and their clinical significance.METHODS:Serum levels of SCF in22controls and116adult patients with CKD were detected by enzyme-linked immunosorbent assay (ELISA) and compared with statistical methods. We analyzed their correlation with the development of renal functional damage, anemia, lipid metabolism disorder, cardiovascular disease and uremic pruritus.RESULTS AND CONCLUSION:Each group of Gender, age and body mass index were all not statistically different,(p>0.05). Blood pressure is higher in patients with CKD compared with healthy control group,(p<0.05). No significant difference in Serum SCF was found between chronic glomerulonephritis, hypertensive nephropathy and diabetic nephropathy,(p>0.05). Serum SCF in different CKD groups were significantly higher than that in control group (all p<0.01). In non-dialytic CKD group, serum SCF increased with the progression of renal dysfunction,(p<0.05). It was positively related to staging of CKD, serum creatinine, blood urea nitrogen, blood high C-reactive protein(CRP), triglyceride and parathormone (r=0.64,0.72,0.52,0.53,0.25,0.52respectively, all p<0.01); while negatively related to blood hemoglobin(r=-0.72, p<0.001). Serum SCF was significantly higher in non-dialytic CKD5group than that in HD group, while Hb was significantly lower(all p<0.01). Serum SCF in CKD patients increases significantly, however, it has no obvious statistical difference among patients with different primary diseases. Serum SCF is closely related to such indicators as serum creatinine and blood hemoglobin. The results suggested that serum SCF may play an importaut role in progression and medical camplications of CKD.