Correlation Between Multi-drug Resistance And HER-2in Breast Cancer

Objective To investigate the correlation between the expression of P170, GST-π, TOTOII and the expression of HER-2in human breast cancer.Methods The expression of HER-2was detected by fluorescence in situ hybridization. The expression of P170, GST-π, TOTOII were tested in48cases breast cancer by immunohistochemical method, and their correlations with clinicopathological feathers and the expression of HER-2were analyzed.Results The positive rate of P170, GST-π, TOTOII were43.8%,39.6%,56.3%respectively. The expression of P170, GST-π, TOTOII positively correlated with the expression of HER-2(P<0.05). The levels of P170, GST-π, TOTOII expression were not associated with age, primary tumor and lymph node metastasis(P>0.05).Conclusion There was great possibility of chemotherapy drug resistance in breast cancer with expression of HER-2. Expressions of P170, GST-π, TOTOII and HER-2have an instructive significance for chemotherapy.