The Relationship Between Subclinical Atherosclerosis And Fasting C-peptide Level In Type2Diabetic Patients

Backgroud&ObjectiveRecent years, the prevalence of diabetes in China was a significant growth, the latest report shows that patients with diabetes in China has surpassed India to become diabetic superpower. Seriously,60.7%of diabetic patients has not been timely and effective treatment, so that the prevalence of chronic complications increased significantly. Macrovascular disease is the main reason for patient’s death and disability,so should be given adequate attention and early prevention. Recently a large number of studies have shown that C-peptide is closely related to chronic complications of diabetes. However, the relationship between C-peptide and diabetic macroangiopathy,and the effect of C-peptide in diabetic macroangiopathy occurrence and development process was uncertainty. We test the C-peptide of diabetic patients with subclinical AS, to explore the relationship between subclinical atherosclerosis and fasting C-peptide level in type2diabetic patients, and the ROC curve to select the best threshold and to evaluate the diagnostic performance. So that we can provide an appropriate basis for prevention and treatment of diabetic macrovascular disease in clinicalMethodsThere were120T2DM patients were collected, and detected carotid arterty. The intima-media thickness (IMT), fasting C-peptide, body mass index(BMI), hemoglobin A1c (HbA1C), low-density lipoprotein (LDL-C), high density lipoprotein (HDL-C), serum cholesterol (CHOL), diastolic pressure (DBP), triglyceride (TG), systolic blood pressure (SBP), understand the course of the disease, smoking history were collected. Any part of IMT quartile1.0mm and (or) appear AS patches and unintentionally, brain, kidney and peripheral vascular disease is defined subclinical AS. According to test results, the patients were divided into subclinical AS group (abnormal group) and non-subclinical AS group (normal group), C-peptide and the indicators of the differences between the two groups were compared, and logistic regression analysis was used to analysis the impact factors of subclinical AS. While using the receiver operating curve (ROC) to study the best threshold of fasting C-peptide levels to diagnosis the subclinical AS and performance evaluation.Results1. Patients in subclinical atherosclerosis group were older,whose FCP,HbA1C,age, BMI, and cholesterol (CHOL), and LDL-C increased higher, than patients in non subclinical atherosclerosis group, and the difference was statistically significant (P<0.05).2. Logistic regression analysis showed that FCP, age, smoking, HbA1C, TG and CHOL were into the statistical equation respectively.3. The ROC curve shows the fasting C-peptide to diagnose subclinical AS best threshold is1.21ng/ml, and there is a certain degree of accuracy (area under the curve0.714), sensitivity of71.6%and specificity of64.2%.Conclusion1. Fasting C-peptide level, age, smoking, hemoglobin A1c, triglyceride, serum cholesterol was the risk factors of subclinical atherosclerosis in type2diabetic patients2. C-peptide, age, smoking, glycated hemoglobin, triglycerides, and serum cholesterol was the risk factors of type2diabetes patients with subclinical atherosclerosis.3. Fasting C-peptide level higher than1.21ng/ml promote the occurrence of subclinical atherosclerosis.