| Background:Sporotrichosis is a fungus infectious disease caused by Sporothrix Schenckii,and the human beings and domestic animals have the same chance to be ill. Sporotrichosis can involve the skin,subcutaneous tissue and nearby lymph system. It distributes in the worldwide,sometimes it outbreaks. In1898Shenck in American reported the disease at first, and separated the pathogen. In1951YangGuoLiang reported1case of the cutaneous sporotrichosis in Shanghai. In1955LiuChunLin reported1case of the cutaneous and systematic sporotrichosis,and emphasised on the pathogen,the clinical and pathological changes. It was the first report about systematic sporotrichosis in China. In1986,Wang reported his research about Sporothrix Schenckii by scanning electron microscopy(SEM). It was the first time report from China by SEM. It’s not easy to give correct diagnosis because sporotrichosis has complex different clinical findings.So It’s necessary for us to make the comprehensive research and analysis about the characteristics of sporotrichosis It will provide the theory for further research and epidemiological prevention.Objective:To make people more deeply understand the disease and bring the guidance and help for the future work by the retrospective analysis of the clinical and pathological characteristics of1146patients with sporotrichosis.We can research the epidemiological feature and the clinical and pathological characteristics,and analyse the reason.These patients,who came from the outpatient department in the Second Hospital of Jilin University during1981-2010,were comformed by clinical and pathological diagnosis.Material and Methods:We collected1146cases of sporotrichosis, from the outpatient department in the Second Hospital of Jilin University during1981-2010.These patients with sporotrichosis were conformed by clinical findings and biopsy.We make the statistical analysis about the clinical and pathological characteristics of patients.These characteristics include gender,age,native place,visiting time,time from presentation,pathogeny,the incidence locations, symptom, sign and pathological characteristics.Results:1. General Information1.1Gender differences:female/male cases=1:1.60.Female over male. 1.2Age is uneven. The minimum age is3months. The most one is87years old. Most people are around the age of40.1.3Profession:The number of farmers is the largest:897cases(78.27%).Others(including students,teachers,leaders and so on):249cases(21.73%).1.4In spring and winter patients are the largest.Spring:(From February to April)452cases(39.44%); Winter:(From November to January)279cases(24.35%).1.5The time from presentation is different. The longest time is30years; The shortest one is3weeks.1.6The time focuses on the year of2005-2006.2. Clinical and pathological characteristics2.1A few people have the injury history:542cases(47.29%).2.2The most parts are limbs and face. Upper limbs:557cases(48.60%);lower limbs:44cases (3.84%);face:403cases (35.16%)2.3The fixed type is the most in the clinical classification:724cases (63.18%).2.4The nodules are seen most in its lesions forms:536cases (46.77%); ulcer:293cases (25.57%); plaque:155cases (13.52%); granuloma:32cases (2.80%); scab:80cases (6.98%); others:50cases (4.36%)2.5Who has aching feeling has the equal number with who has no symptoms. Aching:397cases (34.64%);No symptoms:416cases (36.30%)2.6The different shape cellular granulation is the most in the pathological types:635cases (55.41%).It shows the remarkable plasmocyte hyperplasia.It concludes more or less neutrophile granulocyte,eosinophilic granulocyte,plasmocyte,epithelioid cell and multi-nucleated giant cell.2.758cases underwent a PAS stain, and the positive rate was60.34%.2.8971cases were successfully tracked and were cured.3. Others142cases underwent the fungal culture, and the positive rate was88.73%.65cases underwent the spore fungus element test, and the positive rate was73.85%.Conclusion:1. Sporotrichosis happens in females and in spring and winter mostly.The number of farmers is the largest.2. Sporotrichosis occurs more often in the exposed areas, like limbs and face. 3. Sporotrichosis is caused by Sporothrix Schenckii,and related to the trauma. Infected place is light so it does not cause the attention of the patients. Then the number of who has the injury history is relatively low in the statistical results.4. Sporotrichosis is easy to be missed diagnosed and misdiagnosed for complex different clinical findings,and easy to be mixed up with other diseases. We should be on the alert and do all the relevant inspection programs in the clinical work.5. Visiting time is too long so that it will delay the disease. This reminds us that early detection, early diagnosis and early treatment.6. As the standard of living of modern people is enhancing, many people begin to pay attention to their body. So the number of patients is rising gradually in recent years.7. As long as patients follow the doctor’s advice for treatment, prognosis is relatively satisfactory. |
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