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Study Of Polypropylene Nets To Injury In Rats Vaginal Wall Repairing Muscle And The Biomechanics Of Influence

Posted on:2013-08-12Degree:MasterType:Thesis
Country:ChinaCandidate:Q YangFull Text:PDF
GTID:2234330371983746Subject:Clinical Medicine
Abstract/Summary:PDF Full Text Request
Objectives:Study of polypropylene nets to injury in rats vaginal wall muscle fiber repair, and thebiomechanics of influenceMethod:Select30only adult female weight without kids in200~220g female Wistar ratbetween. Maternal injuries model group only10(that is, eliminate damage vaginal walllookahead organization of pure vaginal wall suture art), maternal injuries polypropylene netspiece of implant group only10(namely the vaginal wall behind the injury implanted patch,and eliminate the polypropylene vaginal wall of the vagina wall was the final organization),and the control group only10(i.e. normal vaginal wall cut final vaginal wall suture tissuesimple operation). Every other Wednesday groups were randomized to two mice put to death,and put the vaginal wall organization since the vaginal vault, and down to a narrow)cylindrical careful separation, according to the vaginal wall muscle fiber direction spiral cutopen the vaginal wall organization, with the tension transducer amplification muscle tensioncontraction signal, observation vaginal wall smooth muscle contraction, and vaginal wallorganization will be fixed, made after the paraffin section with the light microscope andhistopathological evaluations to paralysis formation, inflammatory reaction on board andorganization respectively net long holes1a level4points (1=normal tissue,4=seriousinflammation) results assess. All measuring material all use mean differences and standarddeviation (x and s) said, SPSSl6application. Software for data of statistical analysis,between two groups compares the two single factor analysis of variance, inspectionstandards P=0.05.Results:1the patch of mice vaginal wall smooth muscle contraction force and steady shrinkagetime more than pure vaginal wall of mice repair vaginal wall, but is still less thanJiaShouShu group vaginal wall muscle tension.2with the postoperative recover the extension of time, the patch group and pure vaginalwall during vaginal wall repairing muscle tension are gradually increasing, but the patchgroup more than pure vaginal wall back muscle strength during repair, and the simple vaginal wall muscle strength greater than JiaShouShu group during recovery.3the patch group vaginal wall of mesh in the first week around after HE dyeing notethe amount of inflammatory cell and plenty of red blood cells and new blood vessels, but amonth after the patch group and pure vaginal wall repair group there were no obviousdifference.4simple vaginal wall repair group began wall elasticity and vaginal healing ofincision is better than the patch group.Conclusion:1after injury vaginal wall in implant polypropylene nets tablet can enhance vaginalwall of the contractile force and contraction smooth muscle duration, implantedpolypropylene of the mesh postoperative effect is better than that of traditional simplevaginal wall repair surgery, but vaginal wall muscle tension still cannot meet normal vaginalwall muscle tension level.2vaginal wall smooth muscle in the absence of outside intervention have the ability ofthe self-healing, suggests strengthening exercise and physical therapy after may help restorevaginal wall contraction force.3polypropylene nets of early vaginal wall to implant organization of the mesh foreignbody reaction obvious, is bleeding, at risk of infection period.4polypropylene mesh with vaginal wall organization though has good compatibilityorganization, long-term effect is not very ideal, and self organization has a certain disparity.
Keywords/Search Tags:Pelvic floor disease, Biomechanics, Biological compatibility, Polypropylene mesh
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