| Colon cancer is a common gastrointestinal malignant tumor，In recentyears the incidence of colorectal cancer on the trend of increased year by year，Current treatments have radical surgery colon cancer and postoperativechemotherapy, immune therapy, and other comprehensive therapy。 Treatmentof colon cancer remains poor, domestic reported that patients with colon cancerfive year survival rate is about60%. Colon cancer leading cause of death due tocolon cancer cell metastasis and cancer recurrence. Thereby reducing thesurvival and quality of life of cancer patients. Tumor gene expressionabnormalities, abnormal cell proliferation by the new biology, from molecularbiology to study the escape of tumor stem cells has led to the recurrence andmetastasis of malignant tumors. Its occurrence, the development of morecomplex mechanism of cellular oncogenes and tumor suppressor gene functiondisorder may lead to tumor growth, metastasis and invasion. Investigate thetreatment of tumors from tumor development mechanism to proceed, the tumorto seek early diagnosis, understanding the molecular mechanisms of invasionand metastasis, the new gene therapy targets and accurately determine theprognosis. Study to explore the mechanism of tumorigenesis at the molecularlevel has become the research focus of the current colon cancer. This studyinvestigated the Notch4protein expression in colon cancer tissues and coloncancer in patients with gender, age, degree of cancer differentiation, lymphnode metastasis, distant metastasis, survival situation. I hope to provide atheoretical basis for the diagnosis, treatment and prognosis of coloncancer.Hope for colon cancer diagnosis and treatment to provide the theorybasis.In1919the first Notch genes in fruit flies were found in the body. In recent years, studies found that Notch signaling proteins and individual tumoroccurring and neurodegenerative diseases of close formation. At present, Notchsignal way research has become a developmental biology, cell biology,immunology, hematology and oncology, and other areas of the hotspot.According to reports in the literature, Notch1protein in colon cancer tissue ofthe significantly higher than the normal colonic mucosa of positiveorganization, The expression and Dukes stages and the transfer of lymph nodewere positively correlated. The fourth group of Notch (Notch4) was found onlyin mammals.notch4is different from other three Notch protein which havesmall molecular weight, intracellular short features, Notch4protein2,6, the11EGF kind of repeat sequences are greater than the other subtypes ofcorresponding sequence more than10, respectively the3,3amino acids,It isthe reason for us to study that the great divergence of Notch4, fromthe otherthree Notch genes.Objective: To explore the relations between expression of notch4proteinin human Colon cancer and clinical pathological features an prognosis.Methods: the expression of notch4protein were detect in52cases ofColon cancer and22cases of Ulcerative colitis by tissue immuno-histochemical. It correlations with the clinical pathological notch4protein inColon cancer was assessed.The log-rank survive alanalysis was used toevaluate the relationship between the different groups.Results: The positive expression rate of notch4protein was significantlyhigher in Colon cancer than in Ulcerative colitis (75.00%vs36.36%P<0.05),The expression and the patient’s age, gender, lymph node metastasis, distantmetastases, tumor site, no statistically significant, The expression of notch4protein was negatively correlated to Survival time, differentiation grade.Conclusion:The positive expression rate of notch4protein wassignificantly higher in Colon cancer than in Ulcerative colitis；The expression of notch4protein was negatively correlated to Survival time,differentiationgrade；Notch4may be a novel prognostic marker of Colon cancer. |
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