Analysis Of Effect And Influencing Factors Of Autologous Cultured Melanocyte Transplantation In Treatment Of Stable Vitiligo

Objective: To assess the effectiveness of autologous cultured melanocytetransplantation for vitiligo and analyze the factors influencing the repigmentation.Methods: This is a retrospective study of48patients with stable vitiligo treated byautologous cultured melanocyte transplantation in our department from Oct,2009to Feb,2011. We evaluated the repigmentation by computer software, and did the statistical analysisof the influencing factors like type, location and disease duration on the repigmentation.Among48patients,22were male and26were female; ranging from5-48years of age. Type:generalized18cases, focal17cases and segmental13cases. Location: face and neck22cases, trunk and extremities20cases and joints6cases. Disease duration:≤5years27cases,>5years21cases.Results: Among48patients,34got more than65%repigmentation,19got more than95%repigmentation. The influencing factors: focal and segmental type got better effect thangeneralized type (p=0.002), lesions on face&neck and trunk&extremities got better effectthan joints (p=0.000), no significant impact on the effects was shown by disease duration (p=0.750).Conclusion: Autologous cultured melanocyte transplantation is an effective surgicaltherapy for stable vitiligo. Since influencing factors like type and localization of vitiligoinfluence the repigmentation, they should be taken into account in the selection of patientseligible for this treatment.